TETRACHLOROBISPHENOL A

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H12Cl4O2
Molecular Weight	366.067
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C1=CC(Cl)=C(O)C(Cl)=C1)C2=CC(Cl)=C(O)C(Cl)=C2

InChI

InChIKey=KYPYTERUKNKOLP-UHFFFAOYSA-N

InChI=1S/C15H12Cl4O2/c1-15(2,7-3-9(16)13(20)10(17)4-7)8-5-11(18)14(21)12(19)6-8/h3-6,20-21H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C15H12Cl4O2
Molecular Weight	366.067
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro.	2000 Jul	10869457
2,2',6,6'-Tetrachloro-4,4'-propane-2,2-diyldiphenol, 2,2',6-tribromo-4,4'-propane-2,2-diyldiphenol and 2,2',6,6'-tetrabromo-4,4'-propane-2,2-diyldiphenol.	2001 Nov	11706259
Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A.	2002 Apr 26	12054637
Anaerobic biotransformation of tetrabromobisphenol A, tetrachlorobisphenol A, and bisphenol A in estuarine sediments.	2002 Feb 15	11878385
Effects of the environmental oestrogens bisphenol A, tetrachlorobisphenol A, tetrabromobisphenol A, 4-hydroxybiphenyl and 4,4'-dihydroxybiphenyl on oestrogen receptor binding, cell proliferation and regulation of oestrogen sensitive proteins in the human breast cancer cell line MCF-7.	2003 Apr	12753421
Inhibitory effects of environmental chemicals on protein disulfide isomerase in vitro.	2005 Dec	16617682
Simultaneous determination of tetrabromobisphenol A, tetrachlorobisphenol A, bisphenol A and other halogenated analogues in sediment and sludge by high performance liquid chromatography-electrospray tandem mass spectrometry.	2005 Dec 2	16298182
Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.	2005 Feb 18	15680168
In vitro and in vivo analysis of the thyroid disrupting activities of phenolic and phenol compounds in Xenopus laevis.	2005 Mar	15590892
Biosensor recognition of thyroid-disrupting chemicals using transport proteins.	2006 Feb 15	16478101
Effect of bisphenol A, tetrachlorobisphenol A and pentachlorophenol on the transcriptional activities of androgen receptor-mediated reporter gene.	2006 Nov	16893599
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Bisphenol-A and chlorinated derivatives in adipose tissue of women.	2007 Aug-Sep	17689919
A new bioluminescent cellular assay to measure the transcriptional effects of chemicals that modulate the alpha-1 thyroid hormone receptor.	2007 Sep	17532181
A standardized method for assessment of oxidative transformations of brominated phenols in water.	2008 Jan	17897700
Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay.	2009 Aug	19457453
Determination of tetrabromobisphenol-A, tetrachlorobisphenol-A and bisphenol-A in soil by ultrasonic assisted extraction and gas chromatography-mass spectrometry.	2009 Jul 17	19524246
Characterization of novel ligands of ERα, Erβ, and PPARγ: the case of halogenated bisphenol A and their conjugated metabolites.	2011 Aug	21622942
Biodegradation of bisphenols with immobilized laccase or tyrosinase on polyacrylonitrile beads.	2011 Jun	21125313
Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A.	2011 Sep	21561829
Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis.	2013 Oct	23959441
In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors.	2013 Oct 1	23714657
PBDE: structure-activity studies for the inhibition of hepatitis C virus NS3 helicase.	2014 Apr 2	24699145
Halogenated bisphenol-A analogs act as obesogens in zebrafish larvae (Danio rerio).	2014 May	24591153
Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust.	2015 Feb	25314719

Substance Class	Chemical Created by `admin` on `Sat Dec 16 00:43:12 GMT 2023` Edited by `admin` on `Sat Dec 16 00:43:12 GMT 2023`
Record UNII	FO0P9ET4BN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TETRACHLOROBISPHENOL A

Systematic Name

English

4,4'- (1-METHYLETHYLIDENE)BIS(2,6-DICHLOROPHENOL)

Systematic Name

English

PHENOL, 4,4'-(1-METHYLETHYLIDENE)BIS(2,6-DICHLORO-

Systematic Name

English

2,2-BIS(4-HYDROXY-3,5-DICHLOROPHENYL)PROPANE

Systematic Name

English

3,3',5,5'-TETRACHLOROBISPHENOL A

Common Name

English

NSC-18248

Code

English

NSC-67465

Code

English

PHENOL, 4,4'-ISOPROPYLIDENEBIS(2,6-DICHLORO-

Systematic Name

English

2,2',6,6'-TETRACHLOROBISPHENOL A [HSDB]

Common Name

English

2,2',6,6'-TETRACHLOROBISPHENOL A

Common Name

English

3,5,3',5'-TETRACHLOROBISPHENOL A

Common Name

English

2,2-BIS(3,5-DICHLORO-4-HYDROXYPHENYL)PROPANE

Systematic Name

English

Code System Code Type Description

NSC

18248