FLUMECINOL, (-)-

Details

Stereochemistry	UNKNOWN
Molecular Formula	C16H15F3O
Molecular Weight	280.2849
Optical Activity	( - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(O)(C1=CC=CC=C1)C2=CC=CC(=C2)C(F)(F)F

InChI

InChIKey=DVASNQYQOZHAJN-UHFFFAOYSA-N

InChI=1S/C16H15F3O/c1-2-15(20,12-7-4-3-5-8-12)13-9-6-10-14(11-13)16(17,18)19/h3-11,20H,2H2,1H3

HIDE SMILES / InChI

Molecular Formula	C16H15F3O
Molecular Weight	280.2849
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67016914 | https://www.ncbi.nlm.nih.gov/pubmed/668788 | https://www.ncbi.nlm.nih.gov/pubmed/7918930

FLUMECINOL, a benzhydrol derivative, is a hepatic microsomal drug-metabolizing enzyme inducer. It was in clinical development for the treatment of pruritus associated with primary biliary cirrhosis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cytochromes P450 3 Target ID: Cytochromes P450 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2238704	Activator 1447

PubMed

Title	Date	PubMed
[Efficacy of enzyme-inducing agents in experimental tetrachloromethane poisoning].	2003-10-16	14558353
Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.	2002-09	12512000
[Liver monooxygenase system inducers in the treatment of respiratory distress syndrome in newborn].	2002-03	11980138
[The drop in toxicity and the rise in the effectiveness of antineoplastic chemotherapy by correcting the activity of liver monooxygenases: from the experiment to the clinical practice].	2002	11882969
[Reducing of hepatotoxicity of antineoplastic chemotherapy and concomitant viral infection through control of liver metabolism: from experiment to clinical practice].	2001	11826485

Patents

Sample Use Guides

In Vivo Use Guide

600 mg once weekly for 3 weeks.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:45:33 GMT 2025` Edited by `admin` on `Mon Mar 31 23:45:33 GMT 2025`
Record UNII	FMZ2L5L8WH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUMECINOL, (-)-

Common Name

English

BENZENEMETHANOL, .ALPHA.-ETHYL-.ALPHA.-PHENYL-3-(TRIFLUOROMETHYL)-, (-)-

Preferred Name

English

Code System Code Type Description

FDA UNII

FMZ2L5L8WH

Created by admin on Mon Mar 31 23:45:33 GMT 2025 , Edited by admin on Mon Mar 31 23:45:33 GMT 2025

PRIMARY

CAS

107317-31-7