PALONIDIPINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C29H34FN3O6
Molecular Weight	539.5952
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C2=C(F)C=CC(=C2)[N+]([O-])=O)C(=O)OCC(C)(C)CN(C)CC3=CC=CC=C3

InChI

InChIKey=MUNSLZPCNUVWCH-UHFFFAOYSA-N

InChI=1S/C29H34FN3O6/c1-18-24(27(34)38-6)26(22-14-21(33(36)37)12-13-23(22)30)25(19(2)31-18)28(35)39-17-29(3,4)16-32(5)15-20-10-8-7-9-11-20/h7-14,26,31H,15-17H2,1-6H3

HIDE SMILES / InChI

Molecular Formula	C29H34FN3O6
Molecular Weight	539.5952
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://adisinsight.springer.com/drugs/800001157 | https://www.ncbi.nlm.nih.gov/pubmed/8370558

Palonidipine (also known as TC 81) a calcium antagonist that was developed by Teijin for the treatment of hypertension and angina pectoris. Palonidipine was involved in phase II clinical trials in Japan. However, these studies were discontinued.

Approval Year

PubMed

Title	Date	PubMed
[Effect of palonidipine hydrochloride (TC-81), a new dihydropyridine derivative, on various myocardial ischemic models].	1993-08	8370558
[Effect of palonidipine hydrochloride (TC-81), a novel calcium antagonist, on the canine coronary artery].	1993-07	8335285

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:48:36 GMT 2025` Edited by `admin` on `Mon Mar 31 18:48:36 GMT 2025`
Record UNII	FMS4X67Q96
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

3,5-PYRIDINEDICARBOXYLIC ACID, 4-(2-FLUORO-5-NITROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-, 2,2-DIMETHYL-3-(METHYL(PHENYLMETHYL)AMINO)PROPYL METHYL ESTER

Preferred Name

English

PALONIDIPINE

Official Name

English

3,5-PYRIDINEDICARBOXYLIC ACID, 4-(2-FLUORO-5-NITROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-, 3-(2,2-DIMETHYL-3-(METHYL(PHENYLMETHYL)AMINO)PROPYL) 5-METHYL ESTER

Systematic Name

English

PALONIDIPINE HYDROCHLORIDE [JAN]

Common Name

English

(±)-3-(BENZYLMETHYLAMINO)-2,2-DIMETHYLPROPYL METHYL 4-(2-FLUORO-5-NITROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE

Systematic Name

English

palonidipine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333