1-(1-Naphthalenyl)piperazine

C1CN(CCN1)C2=C3C=CC=CC3=CC=C2

InChIKey=VNICFCQJUVFULD-UHFFFAOYSA-N

InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Serotonin 1a (5-HT1a) receptor 177 Target ID: CHEMBL214 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9397179	Partial Agonist 297	9.2 nM [Ki]
Serotonin 1d (5-HT1d) receptor 53 Target ID: CHEMBL1983 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9397179 \| https://www.ncbi.nlm.nih.gov/pubmed/1565658	Partial Agonist 297	6.2 nM [Ki]
Serotonin 1b (5-HT1b) receptor 45 Target ID: CHEMBL1898 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9397179 \| https://www.ncbi.nlm.nih.gov/pubmed/1565658 \| https://www.ncbi.nlm.nih.gov/pubmed/8863519	Partial Agonist 297	10.1 nM [Ki]
Serotonin 1f (5-HT1f) receptor 15 Target ID: CHEMBL1805 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8380639	Partial Agonist 297	54.0 nM [Ki]
Serotonin 1e (5-HT1e) receptor 6 Target ID: CHEMBL2182 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8380639 \| https://www.ncbi.nlm.nih.gov/pubmed/8863519 \| https://www.ncbi.nlm.nih.gov/pubmed/14744596	Partial Agonist 297	207.0 nM [Ki]

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:45:03 GMT 2025` Edited by `admin` on `Mon Mar 31 22:45:03 GMT 2025`
Record UNII	FJ7MR37A24
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

PIPERAZINE, 1-(1-NAPHTHALENYL)-

Preferred Name

English

1-(1-Naphthalenyl)piperazine

Systematic Name

English

N-(1-Naphthyl)piperazine

Systematic Name

English

1-?-Naphthylpiperazine

Common Name

English

Code System Code Type Description

FDA UNII

FJ7MR37A24