AFALANINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H13NO3
Molecular Weight	207.2258
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC(CC1=CC=CC=C1)C(O)=O

InChI

InChIKey=CBQJSKKFNMDLON-UHFFFAOYSA-N

InChI=1S/C11H13NO3/c1-8(13)12-10(11(14)15)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,12,13)(H,14,15)

HIDE SMILES / InChI

Molecular Formula	C11H13NO3
Molecular Weight	207.2258
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://adisinsight.springer.com/drugs/800003808
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/7340854

AFALANINE was developed by Medea Research in Italy and licensed to Pulitzer. Phase III clinical trials of MR 708 were completed by Pulitzer. Antidepressant; Antiparkinsonian; Neuroprotectant; Nootropic, Dopamine receptor agonist, was used to treat Major depressive disorder.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine receptor 60 Target ID: CHEMBL2096905 Sources: http://adisinsight.springer.com/drugs/800003808	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Major depressive disorder 173 Sources: http://adisinsight.springer.com/drugs/800003808	Primary		Phase III 656	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Isolation and characteristics of immobilized aminoacylase from Streptoverticillium olivoreticuli].	2001 Jan-Feb	11234407

Patents

Sample Use Guides

In Vivo Use Guide

Dogs/rats - AFALANINE (MR-708) produced a mild and transienth hypertension when given to narcotized dogs at the dosage rate of 4.5 mg/kg, and to rats narcotized by bilateral vagotomy at the dosage rate of 5 mg/kg

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:02:38 GMT 2023` Edited by `admin` on `Fri Dec 15 16:02:38 GMT 2023`
Record UNII	FFW2NGO18S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AFALANINE

Official Name

English

NSC-43242

Code

English

N-ACETYL-3-PHENYL-DL-ALANINE

Systematic Name

English

afalanine [INN]

Common Name

English

N-ACETYLPHENYLALANINE, (±)-

Systematic Name

English

N-ACETYLPHENYLALANINE, DL-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265