Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H22N4O2S.2ClH.2H2O |
| Molecular Weight | 479.421 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.Cl.Cl.CN1CCN(CC(=O)N2C3=C(C)SC=C3C(=O)NC4=CC=CC=C24)CC1
InChI
InChIKey=FGZLYNOZVXLZSO-UHFFFAOYSA-N
InChI=1S/C19H22N4O2S.2ClH.2H2O/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22;;;;/h3-6,12H,7-11H2,1-2H3,(H,20,25);2*1H;2*1H2
| Molecular Formula | C19H22N4O2S |
| Molecular Weight | 370.469 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Telenzepine is a selective muscarinic M1 receptor antagonist that was studied for selective inhibition of gastric acid secretion. Telenzepine was used in clinical trials in patients with acute duodenal ulcer, where was found that once daily administration of 3 mg in the evening must be regarded as the optimal dosage regimen of telenzepine. However, the preregistration for peptic ulcer in Germany was discontinued. In addition, the drug was studied in patients with nocturnal asthma. It was shown that telenzepine via the oral route at a dose of up to 5 mg was not effective in preventing nocturnal asthma.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes. | 1989 Apr |
|
| Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. | 1999 Jan 1 |
|
| Distinct muscarinic receptors enhance spontaneous GABA release and inhibit electrically evoked GABAergic synaptic transmission in the chick lateral spiriform nucleus. | 2001 |
|
| Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors. | 2001 Apr |
|
| Interleukin-2 and interleukin-4 increase the survival of retinal ganglion cells in culture. | 2001 Jan 22 |
|
| Muscarinic acetylcholine receptors potentiate the GABAergic transmission in the developing rat inferior colliculus. | 2003 Sep |
|
| Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism. | 2008 Mar 17 |
|
| Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice. | 2009 Jan |
|
| Secretion from acinar cells of the exocrine pancreas: role of enteropancreatic reflexes and cholecystokinin. | 2009 Jan |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 18:08:37 GMT 2023
by
admin
on
Sat Dec 16 18:08:37 GMT 2023
|
| Record UNII |
FC9LY2D3RS
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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FC9LY2D3RS
Created by
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D11098
Created by
admin on Sat Dec 16 18:08:37 GMT 2023 , Edited by admin on Sat Dec 16 18:08:37 GMT 2023
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134822646
Created by
admin on Sat Dec 16 18:08:37 GMT 2023 , Edited by admin on Sat Dec 16 18:08:37 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
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