ZANKIREN HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C35H55N5O6S2.ClH
Molecular Weight	742.432
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC2=CSC=N2)NC(=O)[C@H](CC3=CC=CC=C3)CS(=O)(=O)N4CCN(C)CC4

InChI

InChIKey=KNHOFQRNQBONFF-RWGZXCQOSA-N

InChI=1S/C35H55N5O6S2.ClH/c1-25(2)18-32(41)33(42)30(20-27-12-8-5-9-13-27)37-35(44)31(21-29-22-47-24-36-29)38-34(43)28(19-26-10-6-4-7-11-26)23-48(45,46)40-16-14-39(3)15-17-40;/h4,6-7,10-11,22,24-25,27-28,30-33,41-42H,5,8-9,12-21,23H2,1-3H3,(H,37,44)(H,38,43);1H/t28-,30+,31+,32+,33-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C35H55N5O6S2
Molecular Weight	705.971
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8474102 | https://www.ncbi.nlm.nih.gov/pubmed/7805235 | https://www.ncbi.nlm.nih.gov/pubmed/7697952

Zankiren (A-72517) is a peptidomimetic renin inhibitor with high potency and specificity. The drug was shown to reduce blood pressure in healthy volunteers after oral administration. In another clinical trial, zankiren exerted a renal vasodilator action. Despite positive results from initial clinical trials, further development of zankiren was discontinued.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:35:32 UTC 2023` Edited by `admin` on `Fri Dec 15 18:35:32 UTC 2023`
Record UNII	FB7RZ4HUHJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZANKIREN HYDROCHLORIDE

Official Name

English

ZANKIREN HYDROCHLORIDE [USAN]

Common Name

English

Zankiren hydrochloride [WHO-DD]

Common Name

English

4-THIAZOLEPROPANAMIDE, N-(1-(CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL)-.ALPHA.-((2-(((4-METHYL-1-PIPERAZINYL)SULFONYL)METHYL)-1-OXO-3-PHENYLPROPYL)AMINO)-, MONOHYDROCHLORIDE, (1S-(1R*,(R*(R*)),2S*,3R*))-

Common Name

English

ZANKIREN HCL

Common Name

English

ABBOTT-72517

Code

English

(S)-N-(1S,2R,3S)-1-(Cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-α[(αS)-α-[[(4-methyl-1-piperazinyl)sulfonyl]methyl]hydrocinnamamido]-4-thiazolepropionamide monohydrochloride

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270