5,6-DIMETHOXY-1-INDANONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H12O3
Molecular Weight	192.2112
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1OC)C(=O)CC2

InChI

InChIKey=IHMQOBPGHZFGLC-UHFFFAOYSA-N

InChI=1S/C11H12O3/c1-13-10-5-7-3-4-9(12)8(7)6-11(10)14-2/h5-6H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C11H12O3
Molecular Weight	192.2112
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.google.ch/patents/US6649765 | https://www.ncbi.nlm.nih.gov/pubmed/22885176 | https://www.ncbi.nlm.nih.gov/pubmed/21430053

5,6-Dimethoxy-1-Indanone is used for the organic synthesis. It is an intermediate useful in the preparation of acetylcholinesterase inhibitor Donepezil. 5,6-Dimethoxy-1-Indanone derivatives displayed a potent suppression of the hepatitis C virus (HCV) replication and inhibition of bovine viral diarrhea virus RNA synthesis.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
(2E)-2-Benzyl-idene-5,6-dimethoxy-indan-1-one.	2010-09-11	21587524
Methyl 5,6-dimeth-oxy-1H-indole-2-carboxyl-ate.	2009-09-05	21577822
Photochemical synthesis of substituted indan-1-ones related to donepezil.	2008-05	18465019
Simple and regioselective bromination of 5,6-disubstituted-indan-1-ones with Br2 under acidic and basic conditions.	2007-01-29	17693954
Synthesis of novel, potentially biologically active dibenzosuberone derivatives.	2005-12-31	18007539
Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans.	2001-12-20	11741489

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:19:44 GMT 2025` Edited by `admin` on `Mon Mar 31 22:19:44 GMT 2025`
Record UNII	F805RZI8GO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-401450

Preferred Name

English

5,6-DIMETHOXY-1-INDANONE

Systematic Name

English

1H-INDEN-1-ONE, 2,3-DIHYDRO-5,6-DIMETHOXY-

Systematic Name

English

5,6-DIMETHOXY-2,3-DIHYDRO-1H-INDEN-1-ONE

Systematic Name

English

DONEPEZIL HYDROCHLORIDE MONOHYDRATE IMPURITY B [EP IMPURITY]

Common Name

English

DONEPEZIL HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

5,6-DIMETHOXYINDANE-1-ONE

Systematic Name

English

Code System Code Type Description

FDA UNII

F805RZI8GO