AE-3763

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H34F3N5O7
Molecular Weight	549.5406
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@H](NC(=O)CN1CCN(CC(O)=O)C1=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F

InChI

InChIKey=DHQQXRRWRZFGDW-WBAXXEDZSA-N

InChI=1S/C23H34F3N5O7/c1-12(2)17(19(35)23(24,25)26)28-20(36)14-6-5-7-31(14)21(37)18(13(3)4)27-15(32)10-29-8-9-30(22(29)38)11-16(33)34/h12-14,17-18H,5-11H2,1-4H3,(H,27,32)(H,28,36)(H,33,34)/t14-,17-,18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H34F3N5O7
Molecular Weight	549.5406
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury.	2009 Nov 1	19811924

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:37:01 GMT 2023` Edited by `admin` on `Sat Dec 16 10:37:01 GMT 2023`
Record UNII	F7YC3C4YFS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AE-3763

Code

English

AE3763

Code

English

L-PROLINAMIDE, N-((3-(CARBOXYMETHYL)-2-OXO-1-IMIDAZOLIDINYL)ACETYL)-L-VALYL-N-((1S)-3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPROPYL)-

Systematic Name

English

1-IMIDAZOLIDINEACETIC ACID, 3-(2-(((1S)-2-METHYL-1-(((2S)-2-((((1S)-3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPROPYL)AMINO)CARBONYL)-1-PYRROLIDINYL)CARBONYL)PROPYL)AMINO)-2-OXOETHYL)-2-OXO-

Systematic Name

English

BDBM35279

Code

English

2-(3-(2-(((1S)-2-METHYL-1-((2S)-2-(((1S)-3,3,3-TRIFLUORO-1-ISOPROPYL-2-OXO-PROPYL)CARBAMOYL)PYRROLIDINE-1-CARBONYL)PROPYL)AMINO)-2-OXO-ETHYL)-2-OXO-IMIDAZOLIDIN-1-YL)ACETIC ACID

Systematic Name

English

Code System Code Type Description

FDA UNII

F7YC3C4YFS

Created by admin on Sat Dec 16 10:37:01 GMT 2023 , Edited by admin on Sat Dec 16 10:37:01 GMT 2023

PRIMARY

PUBCHEM

9807572

Created by admin on Sat Dec 16 10:37:01 GMT 2023 , Edited by admin on Sat Dec 16 10:37:01 GMT 2023

PRIMARY

CAS

291778-77-3

Created by admin on Sat Dec 16 10:37:01 GMT 2023 , Edited by admin on Sat Dec 16 10:37:01 GMT 2023

PRIMARY

Related Record Type Details


					F7YC3C4YFS

AE-3763

ACTIVE MOIETY

Comments:

Infusion of AE-3763 dose-dependently prevented LPS-induced lung oedema and the infiltration of white blood cells into the hamster lung. AE-3763 also attenuated intratracheal HNE-induced hamster lung haemorrhage with ED50 values of 0.4 mg/kg/h and 1.3 mg/kg by intravenous infusion and intravenous bolus injection, respectively.


					F7YC3C4YFS

AE-3763

ACTIVE MOIETY

Comments:

Class: Imidazolines, Pyrrolidines; Mechanism of Action: Leucocyte elastase inhibitor; Highest Development Phase: Discontinued for Acute lung injury and Adult respiratory distress syndrome