Tixestobart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 16:50:06 GMT 2025` Edited by `admin` on `Wed Apr 02 16:50:06 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|LAMDA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	F6V3QF5HAK
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Tixestobart

Official Name

English

GEN-1053

Preferred Name

English

GEN1053

Code

English

tixestobart [INN]

Common Name

English

immunoglobulin G1-lambda2, anti-[Homo sapiens CD27 (TNFRSF7, tumor necrosis factor receptor (TNFR) superfamily member 7)], Homo sapiens monoclonal antibody (H-gamma1 heavy chain Homo sapiens (1-445) [VH (Homo sapiens IGHV7-4-1*02 (91.8%) -(IGHD) -IGHJ4*0

Common Name

English

Immunoglobulin G1 [102-serine,328-arginine,344-arginine,de-C-terminal-lysine], anti-(human CD27 antigen) (human monoclonal IgG1-7730-143-C102S-RR ?1-chain), disulfide with human monoclonal IgG1-7730-143-C102S-RR ?-chain, dimer

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C189061

Created by admin on Wed Apr 02 16:50:06 GMT 2025 , Edited by admin on Wed Apr 02 16:50:06 GMT 2025

PRIMARY

CAS

2733575-82-9

Created by admin on Wed Apr 02 16:50:06 GMT 2025 , Edited by admin on Wed Apr 02 16:50:06 GMT 2025

PRIMARY

INN

13358

Created by admin on Wed Apr 02 16:50:06 GMT 2025 , Edited by admin on Wed Apr 02 16:50:06 GMT 2025

PRIMARY

FDA UNII

F6V3QF5HAK

Created by admin on Wed Apr 02 16:50:06 GMT 2025 , Edited by admin on Wed Apr 02 16:50:06 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_143	2_199
2_219	4_215
2_260	2_320
1_143	1_199
2_366	2_424
3_22	3_90
3_138	3_197
4_22	4_90
4_138	4_197
1_219	3_215
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					NJG4CJ69BB

CD27 ANTIGEN

TARGET->LIGAND

Amount:

Related Record Type Details


					F6V3QF5HAK

Tixestobart

ACTIVE MOIETY

Comments:

Cluster of differentiation (CD)27 is an important costimulatory receptor on T cells and CD27 agonism is hypothesized to increase anti-tumor immunity

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL