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Details

Stereochemistry ACHIRAL
Molecular Formula C2H4N4O2S2
Molecular Weight 180.209
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DESACETYL ACETAZOLAMIDE

SMILES

NC1=NN=C(S1)S(N)(=O)=O

InChI

InChIKey=VGMVBPQOACUDRU-UHFFFAOYSA-N
InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8)

HIDE SMILES / InChI

Molecular Formula C2H4N4O2S2
Molecular Weight 180.209
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Bile acid derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibition effects.
2002 Aug
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
2003 May 22
Carbonic anhydrase inhibitors: Schiff's bases of aromatic and heterocyclic sulfonamides and their metal complexes.
2004 Jun
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides.
2005 Aug
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
2005 Jan 17
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.
2006 Dec 15
Amide derivatives with pyrazole carboxylic acids of 5-amino-1,3,4-thiadiazole 2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibitory effects.
2008 Dec
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.
2009 Apr
Simultaneous determination of epinephrine, uric acid and xanthine in the presence of ascorbic acid using an ultrathin polymer film of 5-amino-1,3,4-thiadiazole-2-thiol modified electrode.
2009 Aug 4
Effects of new 5-amino-1,3,4-thiadiazole-2-sulfonamide derivatives on human carbonic anhydrase isozymes.
2009 May 1
Acetazolamide-based fungal chitinase inhibitors.
2010 Dec 1
Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide.
2010 Nov
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 17:35:34 GMT 2023
Edited
by admin
on Fri Dec 15 17:35:34 GMT 2023
Record UNII
F687N81LIZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DESACETYL ACETAZOLAMIDE
Common Name English
NSC-22979
Code English
ACETAZOLAMIDE RELATED COMPOUND D [USP-RS]
Common Name English
2-AMINO-1,3,4-THIADAZOLE-5-SULFONAMIDE
Common Name English
5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
Systematic Name English
ACETAZOLAMIDE IMPURITY D [EP IMPURITY]
Common Name English
TIO-URASIN
Common Name English
2-AMINO-1,3,4-THIADIAZOLE-5-SULFONAMIDE
Systematic Name English
DESACETYL ACETAZOLAMIDE [USP IMPURITY]
Common Name English
CL-5343
Code English
5-AMINO-1,3,4-THIADIAZOL-2-SULFONAMIDE
Systematic Name English
1,3,4-THIADIAZOLE-2-SULFONAMIDE, 5-AMINO-
Systematic Name English
AMINO-1,3,4-THIADIAZOLE-5-SULFONAMIDE, 2-
Systematic Name English
Code System Code Type Description
FDA UNII
F687N81LIZ
Created by admin on Fri Dec 15 17:35:35 GMT 2023 , Edited by admin on Fri Dec 15 17:35:35 GMT 2023
PRIMARY
CAS
14949-00-9
Created by admin on Fri Dec 15 17:35:34 GMT 2023 , Edited by admin on Fri Dec 15 17:35:34 GMT 2023
PRIMARY
RS_ITEM_NUM
1005048
Created by admin on Fri Dec 15 17:35:35 GMT 2023 , Edited by admin on Fri Dec 15 17:35:35 GMT 2023
PRIMARY
NSC
22979
Created by admin on Fri Dec 15 17:35:35 GMT 2023 , Edited by admin on Fri Dec 15 17:35:35 GMT 2023
PRIMARY
PUBCHEM
84724
Created by admin on Fri Dec 15 17:35:35 GMT 2023 , Edited by admin on Fri Dec 15 17:35:35 GMT 2023
PRIMARY
EPA CompTox
DTXSID10164324
Created by admin on Fri Dec 15 17:35:35 GMT 2023 , Edited by admin on Fri Dec 15 17:35:35 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP