MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:23:38 GMT 2025` Edited by `admin` on `Tue Apr 01 19:23:38 GMT 2025`
Protein Type	ENZYME
Protein Sub Type	SERINE/THREONINE-PROTEIN KINASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	F5TUJ1SE0X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8

Common Name

English

CANCER OSAKA THYROID ONCOGENE

Preferred Name

English

ESTF

Common Name

English

TPL-2

Common Name

English

SERINE/THREONINE-PROTEIN KINASE COT

Common Name

English

PROTO-ONCOGENE C-COT

Common Name

English

TUMOR PROGRESSION LOCUS 2

Common Name

English

Code System Code Type Description

UNIPROT

P41279

Created by admin on Tue Apr 01 19:23:38 GMT 2025 , Edited by admin on Tue Apr 01 19:23:38 GMT 2025

PRIMARY

FDA UNII

F5TUJ1SE0X

Created by admin on Tue Apr 01 19:23:38 GMT 2025 , Edited by admin on Tue Apr 01 19:23:38 GMT 2025

PRIMARY

WIKIPEDIA

MAP3K8

Created by admin on Tue Apr 01 19:23:38 GMT 2025 , Edited by admin on Tue Apr 01 19:23:38 GMT 2025

PRIMARY

PHAROS

P41279

Created by admin on Tue Apr 01 19:23:38 GMT 2025 , Edited by admin on Tue Apr 01 19:23:38 GMT 2025

PRIMARY

Related Record Type Details


					A8Y5K4G762

TILPISERTIB

INHIBITOR -> TARGET

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_62] [1_141] [1_400] [1_443]		S		DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_80] [1_290]		T		THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL