LAPRAFYLLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C29H36N6O2
Molecular Weight	500.6351
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CN1C2=C(N=C(CCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)N2)C(=O)N(C)C1=O

InChI

InChIKey=OEHQNUNEMMXGRU-UHFFFAOYSA-N

InChI=1S/C29H36N6O2/c1-21(2)20-35-27-25(28(36)32(3)29(35)37)30-24(31-27)14-15-33-16-18-34(19-17-33)26(22-10-6-4-7-11-22)23-12-8-5-9-13-23/h4-13,21,26H,14-20H2,1-3H3,(H,30,31)

HIDE SMILES / InChI

Molecular Formula	C29H36N6O2
Molecular Weight	500.6351
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2835053 | https://www.ncbi.nlm.nih.gov/pubmed/2395105

LAPRAFYLLINE is a xanthine derivative with bronchodilating effect. It might exert its action by inhibiting cAMP phosphodiesterase.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of the methyl xanthine S 9795 on isolated bronchi of the dog.	1990-09	2395105
Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats.	1989-07-01	2612517
Effects of progressively increased doses of theophylline and of S 9795 on hemodynamics, blood gases and lung mechanics in dogs.	1988-07-01	3233049
Pharmacological properties of a new antiasthmatic xanthine derivative devoid of central stimulatory activity.	1987-12	2835053

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:07 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:07 GMT 2025`
Record UNII	F427P36M7J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

laprafylline [INN]

Preferred Name

English

LAPRAFYLLINE

Official Name

English

8-(2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHYL)-3-ISOBUTYL-1-METHYLXANTHINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319