FLUSILAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H15F2N3Si
Molecular Weight	315.3927
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[Si](CN1C=NC=N1)(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3

InChI

InChIKey=FQKUGOMFVDPBIZ-UHFFFAOYSA-N

InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C16H15F2N3Si
Molecular Weight	315.3927
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30673466 | https://www.ncbi.nlm.nih.gov/pubmed/17187383

Flusilazole, a member of the demethylation inhibitor fungicides, is highly efficacious for control of fungal infections on a variety of fruit and vegetable crops. Experiments on rodents have shown the marked maternal toxicity, growth retardation, and skeletal abnormalities in the mid- and high-dose groups.

Approval Year

PubMed

Title	Date	PubMed
Comparison of microextraction procedures to determine pesticides in oranges by liquid chromatography-mass spectrometry.	2002 Sep 13	12350094
Determination of seventeen polar/thermolabile pesticides in apples and apricots by liquid chromatography/mass spectrometry.	2003 May-Jun	12852583
Pesticide residues on the external surfaces of field crop sprayers: occupational exposure.	2005 Jun	15650013
Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.).	2006	17390857
Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.	2006 Nov 10	16989930
Citral, an inhibitor of retinoic acid synthesis, attenuates the frequency and severity of branchial arch abnormalities induced by triazole-derivative fluconazole in rat embryos cultured in vitro.	2007 Nov-Dec	17875381
Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line.	2008 May 30	18513395
Optimization of separation and detection conditions for the multiresidue analysis of pesticides in grapes by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.	2008 May 9	18371973
Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn).	2012 Aug 1	22634333
A high-throughput screen for teratogens using human pluripotent stem cells.	2014 Jan	24154490
Comparison of osteoblast and cardiomyocyte differentiation in the embryonic stem cell test for predicting embryotoxicity in vivo.	2014 Sep	24704097
Combination effects of (tri)azole fungicides on hormone production and xenobiotic metabolism in a human placental cell line.	2014 Sep 17	25233012

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:49:25 UTC 2023` Edited by `admin` on `Fri Dec 15 17:49:25 UTC 2023`
Record UNII	F3WG2VVD87
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUSILAZOLE

Common Name

English

FLUSILAZOLE [MI]

Common Name

English

FLUSILAZOLE [ISO]

Common Name

English

PUNCH

Brand Name

English

NUSTAR

Brand Name

English

BIS(4-FLUOROPHENYL)(METHYL)(1H-1,2,4-TRIAZOL-1-YLMETHYL)SILANE

Systematic Name

English

OLYMP

Brand Name

English

1-((BIS(4-FLUOROPHENYL)METHYLSILYL)METHYL)-1H-1,2,4-TRIAZOLE

Systematic Name

English

FLUZILAZOL

Common Name

English

DPX-H6573

Code

English

Classification Tree Code System Code

EPA PESTICIDE CODE

128835