Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H15F2N3Si |
| Molecular Weight | 315.3927 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[Si](CN1C=NC=N1)(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
InChI
InChIKey=FQKUGOMFVDPBIZ-UHFFFAOYSA-N
InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3
| Molecular Formula | C16H15F2N3Si |
| Molecular Weight | 315.3927 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Flusilazole, a member of the demethylation inhibitor fungicides, is highly efficacious for control of fungal infections on a variety of fruit and vegetable crops. Experiments on rodents have shown the marked maternal toxicity, growth retardation, and skeletal abnormalities in the mid- and high-dose groups.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. | 2016-01-15 |
|
| Combination effects of (tri)azole fungicides on hormone production and xenobiotic metabolism in a human placental cell line. | 2014-09-17 |
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| Comparison of osteoblast and cardiomyocyte differentiation in the embryonic stem cell test for predicting embryotoxicity in vivo. | 2014-09 |
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| A high-throughput screen for teratogens using human pluripotent stem cells. | 2014-01 |
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| Triazole induced concentration-related gene signatures in rat whole embryo culture. | 2012-09 |
|
| Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn). | 2012-08-01 |
|
| Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure. | 2012-05 |
|
| Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals. | 2011-09 |
|
| Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test. | 2011-03-05 |
|
| Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures. | 2011-03-01 |
|
| Integrated palladium-catalyzed arylation of heavier Group 14 hydrides. | 2010-12-03 |
|
| Determination of fungicides in wine by mixed-mode solid phase extraction and liquid chromatography coupled to tandem mass spectrometry. | 2010-11-26 |
|
| Ecotoxicological effects of rice field waters on selected planktonic species: comparison between conventional and organic farming. | 2010-11 |
|
| Effects of fungicides on in vitro spore germination and mycelial growth of the phytopathogens Leptosphaeria maculans and L. biglobosa (phoma stem canker of oilseed rape). | 2010-04 |
|
| Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. | 2010-03-15 |
|
| Multi-residue analysis of 30 currently used pesticides in fine airborne particulate matter (PM 2.5) by microwave-assisted extraction and liquid chromatography-tandem mass spectrometry. | 2009-12-18 |
|
| In vitro toxicity of selected fungicides from the groups of benzimidazoles and demethylation inhibitors to Cladobotryum dendroides and Agaricus bisporus. | 2009-05 |
|
| Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line. | 2008-05-30 |
|
| Optimization of separation and detection conditions for the multiresidue analysis of pesticides in grapes by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. | 2008-05-09 |
|
| [Occurrence of plant protection product residues in apples in 2007]. | 2008 |
|
| Citral, an inhibitor of retinoic acid synthesis, attenuates the frequency and severity of branchial arch abnormalities induced by triazole-derivative fluconazole in rat embryos cultured in vitro. | 2007-04-11 |
|
| Developmental toxic effects of antifungal flusilazole administered by gavage to mice. | 2007-02 |
|
| Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles. | 2006-11-10 |
|
| Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects. | 2006-08 |
|
| Transferability of six pesticides from agricultural sprayer surfaces. | 2006-04 |
|
| Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.). | 2006 |
|
| Study on the common teratogenic pathway elicited by the fungicides triazole-derivatives. | 2005-09 |
|
| Pesticide residues on the external surfaces of field crop sprayers: occupational exposure. | 2005-06 |
|
| Determination of azolic fungicides in wine by solid-phase extraction and high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. | 2005-05-27 |
|
| Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. | 2004-08 |
|
| Pesticide residues on the external surfaces of field-crop sprayers: environmental impact. | 2004-08 |
|
| Application of liquid chromatography with electrospray tandem mass spectrometry to the determination of a new generation of pesticides in processed fruits and vegetables. | 2004-05-21 |
|
| Determination of seventeen polar/thermolabile pesticides in apples and apricots by liquid chromatography/mass spectrometry. | 2003-07-11 |
|
| Comparison of microextraction procedures to determine pesticides in oranges by liquid chromatography-mass spectrometry. | 2002-09-13 |
|
| Baseline toxicity of several pesticides to Hyaliodes vitripennis (Say) (Hemiptera: Miridae). | 2001-11 |
|
| Simultaneous determination of six triazolic pesticide residues in apple and pear pulps by liquid chromatography with ultraviolet diode array detection. | 2001-10-17 |
|
| Antifungal triazoles induce malformations in vitro. | 2001-08-08 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:54:01 GMT 2025
by
admin
on
Mon Mar 31 18:54:01 GMT 2025
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| Record UNII |
F3WG2VVD87
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| Record Status |
Validated (UNII)
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| Record Version |
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EPA PESTICIDE CODE |
128835
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73675
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300000053334
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flusilazole
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85509-19-9
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81922
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FLUSILAZOLE
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m5506
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PRIMARY | Merck Index | ||
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F3WG2VVD87
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DTXSID3024235
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