Poliglusam (also commonly known as chitosan) is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine and N-acetyl-D-glucosamine. Commercial Poliglusam is derived from deacetylation of chitin contained in the shells of various sea crustaceans such as shrimps. Chitosan is easily prepared from the second most plentiful natural polymer on earth, so it is no surprise that it is being researched as a key component of so many different biomaterials. Several benefits of Poliglusam, such as biocompatibility, biodegradability, biorenewability, bioadhesivity, and nontoxicity have made them important natural polymers for pharmaceutical and cosmetic industries. Poliglusam and its derivatives are biocompatible in a wide range of applications, from hydrogels promoting angiogenesis to a bread supplement that ameliorates diabetes. Poliglusam is also used within some wound dressings to stop bleeding. In agriculture, chitosan is typically used as a natural seed treatment and plant growth enhancer, and as an ecologically friendly biopesticide substance that boosts the innate ability of plants to defend themselves against fungal infections. As a rich source of dietary fiber, chitosan is used as a food ingredient or additive.
Approval Year
PubMed
Title | Date | PubMed |
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Reconstruction of epidermis on a chitosan cross-linked collagen-GAG lattice: effect of fibroblasts. | 1993 Jun |
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Evaluation of effects of chitosan in preventing hemorrhagic cystitis in rats induced by cyclophosphamide. | 1995 Apr |
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[Evaluation of the usefulness of dressings made from chitosan and lyophilized human placenta on wound healing]. | 1997 |
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Further biocompatibility testing of silica-chitosan complex membrane in the production of tissue plasminogen activator by epithelial and fibroblast cells. | 1999 |
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Healing at skin graft donor sites dressed with chitosan. | 2000 Oct |
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The effect of chitosan on stiffness and glycolytic activity of human bladder cells. | 2001 Aug 22 |
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The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. | 2001 Nov |
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Chitosan for mucosal vaccination. | 2001 Nov 5 |
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[Effect of chitosan in complex management of obesity]. | 2002 Aug |
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Nerve regeneration in a collagen-chitosan tissue-engineered skin transplanted on nude mice. | 2003 Apr |
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[Regeneration of the axotomised sciatic nerve in dogs using the tubulisation technique with Chitosan biomaterial preloaded with progesterone]. | 2003 Jun 16-30 |
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Antioxidative effect of chitosan on chronic carbon tetrachloride induced hepatic injury in rats. | 2003 May 1 |
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Characterization and blood coagulation evaluation of the water-soluble chitooligosaccharides prepared by a facile fractionation method. | 2003 Nov-Dec |
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Sodium citrate cross-linked chitosan films: optimization as substitute for human/rat/rabbit epidermal sheets. | 2004 Dec 20 |
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[The study of influence of chitosan on clinical, metabolic and immune parameters in patients with cardiovascular diseases]. | 2005 |
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[Mechanisms of action of transportation of liposomes and chitosan-coated liposomes containing leuprolide across intestine and Caco-2 cell]. | 2005 Jan |
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Efficacy of an intratumoral controlled release formulation of clusterin antisense oligonucleotide complexed with chitosan containing paclitaxel or docetaxel in prostate cancer xenograft models. | 2005 Sep |
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Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats. | 2006 Feb 15 |
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Homogeneous chitosan-PLGA composite fibrous scaffolds for tissue regeneration. | 2008 Jan |
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Preparation of chitosan-polyaspartic acid-5-fluorouracil nanoparticles and its anti-carcinoma effect on tumor growth in nude mice. | 2008 Jun 14 |
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Effects of PDT with 5-aminolevulinic acid and chitosan on Walker carcinosarcoma. | 2008 Sep |
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Uptake and cytotoxicity of chitosan nanoparticles in human liver cells. | 2010 Dec 1 |
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Fungal cell wall agents suppress the innate inflammatory cytokine responses of human peripheral blood mononuclear cells challenged with lipopolysaccharide in vitro. | 2011 Aug |
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Curcumin encapsulated in chitosan nanoparticles: a novel strategy for the treatment of arsenic toxicity. | 2012 Jul 30 |
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Low molecular weight chitosan accelerates glucagon-like peptide-1 secretion in human intestinal endocrine cells via a p38-dependent pathway. | 2013 May 22 |
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Chitooligosaccharides attenuate Cu2+-induced cellular oxidative damage and cell apoptosis involving Nrf2 activation. | 2015 May |
Substance Class |
Polymer
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SALT/SOLVATE -> PARENT |
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
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Agent Modifications
Modification Process | Modification Role | Modification Type | Amount | Fragment Name | Fragment ID |
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SALT FORMATION | CHEMICAL |
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Hydrochloric acid | QTT17582CB |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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VISCOSITY | PHYSICAL |
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