6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H27Cl2N5O2
Molecular Weight	512.431
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Structure Search

SMILES

CCN(CC)CCOC1=CC=C(NC2=NC3=C(C=N2)C=C(C(=O)N3C)C4=C(Cl)C=CC=C4Cl)C=C1

InChI

InChIKey=IFPPYSWJNWHOLQ-UHFFFAOYSA-N

InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)

HIDE SMILES / InChI

Molecular Formula	C26H27Cl2N5O2
Molecular Weight	512.431
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Proto-oncogene tyrosine-protein kinase Src 8 Target ID: P12931 Gene ID: 6714.0 Gene Symbol: SRC Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/9400019	Inhibitor 8504	8.4 nM [IC50]
Fibroblast growth factor receptor 1 46 Target ID: P11362\|\|\|Q14307\|\|\|Q9UDF2 Gene ID: 2260.0 Gene Symbol: FGFR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/9400019	Inhibitor 8504	39.3 nM [IC50]
Epidermal growth factor receptor 49 Target ID: P00533\|\|\|Q9GZX1 Gene ID: 1956.0 Gene Symbol: EGFR Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/9400019	Inhibitor 8504	87.5 nM [IC50]
Platelet-derived growth factor receptor beta 56 Target ID: P09619 Gene ID: 5159.0 Gene Symbol: PDGFRB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/9400019	Inhibitor 8504	98.3 nM [IC50]

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:22:02 GMT 2025` Edited by `admin` on `Tue Apr 01 16:22:02 GMT 2025`
Record UNII	F2UH9R2JT6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Systematic Name

English

PD-0166285

Preferred Name

English

TCMDC-140940

Code

English

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-

Systematic Name

English

PD166285

Code

English

PD-166285

Code

English

Code System Code Type Description

FDA UNII

F2UH9R2JT6