Cellacefate is a commonly used polymer phthalate in the formulation of pharmaceuticals, such as the enteric coating of tablets or capsules and for controlled release formulations. Cellacefate's use in enteric coatings allows tablets to remain intact in the unfavorable gastric acid secretion of the stomach, but dissolve in the more basic areas of the duodenum, thus protecting the stomach from ulceration or allowing greater absorption form the duodenum. Cellacefate is a reaction product of phthalic anhydride and a partial acetate ester of cellulose.
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Polymer
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Sat Dec 16 13:13:33 GMT 2023
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F2O5O2OI9F
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CELLACEFATE
Created by
admin on Sat Dec 16 13:13:33 GMT 2023 , Edited by admin on Sat Dec 16 13:13:33 GMT 2023
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PRIMARY | Description: A white, free-flowing powder or colourless flakes; odourless or with a faint odour of acetic acid.Solubility: Practically insoluble in water and ethanol (~750 g/l) TS; freely soluble in acetone R; soluble in dioxan R; dissolves indilute solutions of alkali. Category: Enteric coating agent for solid oral dosage forms. Storage: Cellacefate should be kept in a well-closed container, and stored in a cool and dry place. Additional information: Cellacefate is hygroscopic. Definition: Cellacefate is a cellulose, some of the hydroxyl groups of which are esterified by phthaloyl groups and others by acetylgroups. | ||
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Cellulose acetate phthalate
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