Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C19H21NO5.ClH |
Molecular Weight | 379.835 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C(CNC[C@H]1COC2=C(O1)C=CC=C2)COC3=CC=C4OCOC4=C3
InChI
InChIKey=GGNCUSDIUUCNKE-RSAXXLAASA-N
InChI=1S/C19H21NO5.ClH/c1-2-5-18-16(4-1)22-12-15(25-18)11-20-8-3-9-21-14-6-7-17-19(10-14)24-13-23-17;/h1-2,4-7,10,15,20H,3,8-9,11-13H2;1H/t15-;/m0./s1
Molecular Formula | C19H21NO5 |
Molecular Weight | 343.3737 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Osemozotan (also known as MKC-242) was developed as a selective 5-HT1A receptor agonist. Experiments on animal have shown that osemozotan improved most abnormal behaviors such as isolation rearing. Osemozotan was being investigated for the treatment of pain, aggressive behavior, anxiety, depression, obsessive-compulsive disorder, and drug dependence with methamphetamine and cocaine. However, all these studies were suspended. In the USA osemozotan participated in phase II clinical trial for the insomnia patients, however, the study was terminated because of the license agreement.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL214 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8786639 |
0.35 nM [Ki] |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:36:26 UTC 2023
by
admin
on
Fri Dec 15 16:36:26 UTC 2023
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Record UNII |
F0WKFYPQL8
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Record Status |
Validated (UNII)
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Record Version |
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DTXSID00929762
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198746
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137275-80-0
Created by
admin on Fri Dec 15 16:36:26 UTC 2023 , Edited by admin on Fri Dec 15 16:36:26 UTC 2023
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F0WKFYPQL8
Created by
admin on Fri Dec 15 16:36:26 UTC 2023 , Edited by admin on Fri Dec 15 16:36:26 UTC 2023
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |