Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H21NO5.ClH |
| Molecular Weight | 379.835 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C(CNC[C@H]1COC2=C(O1)C=CC=C2)COC3=CC=C4OCOC4=C3
InChI
InChIKey=GGNCUSDIUUCNKE-RSAXXLAASA-N
InChI=1S/C19H21NO5.ClH/c1-2-5-18-16(4-1)22-12-15(25-18)11-20-8-3-9-21-14-6-7-17-19(10-14)24-13-23-17;/h1-2,4-7,10,15,20H,3,8-9,11-13H2;1H/t15-;/m0./s1
| Molecular Formula | C19H21NO5 |
| Molecular Weight | 343.3737 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Osemozotan (also known as MKC-242) was developed as a selective 5-HT1A receptor agonist. Experiments on animal have shown that osemozotan improved most abnormal behaviors such as isolation rearing. Osemozotan was being investigated for the treatment of pain, aggressive behavior, anxiety, depression, obsessive-compulsive disorder, and drug dependence with methamphetamine and cocaine. However, all these studies were suspended. In the USA osemozotan participated in phase II clinical trial for the insomnia patients, however, the study was terminated because of the license agreement.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice. | 2001 Dec 7 |
|
| Functional alteration of brain dopaminergic system in isolated aggressive mice. | 2001 Sep |
|
| Modulation by 5-hT2A receptors of aggressive behavior in isolated mice. | 2002 May |
|
| Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice. | 2002 Oct |
|
| The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze. | 2003 Jan 1 |
|
| The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice. | 2003 Oct |
|
| Inhibitory action of 5-HT1A agonist MKC-242 on triazolam-induced phase advances in hamster circadian activity rhythms. | 2005 May |
|
| Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice. | 2006 Dec 1 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:36:26 GMT 2023
by
admin
on
Fri Dec 15 16:36:26 GMT 2023
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| Record UNII |
F0WKFYPQL8
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| Record Status |
Validated (UNII)
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| Record Version |
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198746
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137275-80-0
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F0WKFYPQL8
Created by
admin on Fri Dec 15 16:36:26 GMT 2023 , Edited by admin on Fri Dec 15 16:36:26 GMT 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
