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Details

Stereochemistry ABSOLUTE
Molecular Formula C62H88N13O14P.C10H12N5O3.Co
Molecular Weight 1579.5818
Optical Activity UNSPECIFIED
Defined Stereocenters 17 / 18
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBAMAMIDE

SMILES

[Co+3].[CH2-][C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=NC3=C2N=CN=C3N.C[C@H](CNC(=O)CC[C@]4(C)[C@@H](CC(N)=O)C5[N-]C4=C(C)C6=NC(=CC7=NC(=C(C)C8=N[C@]5(C)[C@@](C)(CC(N)=O)[C@@H]8CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]7CCC(N)=O)C(C)(C)[C@@H]6CCC(N)=O)OP([O-])(=O)O[C@@H]9[C@@H](CO)O[C@@H]([C@@H]9O)N%10C=NC%11=C%10C=C(C)C(C)=C%11

InChI

InChIKey=OAJLVMGLJZXSGX-NDSREFPTSA-L
InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56?,57+,59-,60+,61+,62+;4-,6-,7+,10-;/m11./s1

HIDE SMILES / InChI
Molecular Formula Co
Molecular Weight 58.9332
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C10H11N5O3
Molecular Weight 249.226
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula C62H89N13O14P
Molecular Weight 1271.4225
Charge -1
Count
Stereochemistry EPIMERIC
Additional Stereochemistry No
Defined Stereocenters 13 / 14
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Cobamamide is one of the active forms of vitamin B12 that is also known as adenosylcobalamin or dibencozide. This drug is available as a nutritional supplement to prevent the vitamin B12 deficiency. Liposomal formulation of cobamamide was developed for the treatment of atopic dermatitis by a Korean company Hanall Biopharma.

Approval Year

2011
587
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
PubMed

PubMed

TitleDatePubMed
Inhibition of productive human immunodeficiency virus-1 infection by cobalamins.
1995 Aug 15
Substance Class Chemical
Created
by admin
on Sat Dec 16 20:10:39 GMT 2023
Edited
by admin
on Sat Dec 16 20:10:39 GMT 2023
Record UNII
F0R1QK73KB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COBAMAMIDE
INCI   INN   JAN   MI   WHO-DD  
INCI   INN  
Official Name English
DBC
Common Name English
5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE 5'-DEOXYADENOSINE
Common Name English
COENZILE
Brand Name English
5'-DEOXYADENOSYL-B12
Common Name English
HL-009
Code English
INDUSIL
Brand Name English
COBAMAMIDE [JAN]
Common Name English
COENZYME B12
Common Name English
COBANZYME
Brand Name English
ADOCBL
Common Name English
COBAMAMIDUM
Common Name English
ADEMIDE
Brand Name English
HERACLENE
Brand Name English
COBAMAMIDE [INCI]
Common Name English
COBAMAMIDE [MI]
Common Name English
NSC-757791
Code English
DIBENZCOZAMIDE
Common Name English
cobamamide [INN]
Common Name English
Cobamamide [WHO-DD]
Common Name English
VITAMIN B12 COENZYME
Common Name English
LM 176
Code English
5'-DEOXYADENOSYLCOBALAMIN
Common Name English
COBINAMIDE, CO-(5'-DEOXYADENOSIN-5'-YL)-, F-(DIHYDROGEN PHOSPHATE), INNER SALT, 3'-ESTER WITH (5,6-DIMETHYL-1-.ALPHA.-D-RIBOFURANOSYL-1H-BENZIMIDAZOLE-.KAPPA.N3)
Common Name English
LM-176
Code English
DIMEBENZCOZAMIDE
Common Name English
COBALTAMIN S
Brand Name English
ENZICOBA
Brand Name English
COBAMAMIDE [USP-RS]
Common Name English
ADENOSYL-B12
Common Name English
CALOMIDE
Brand Name English
Classification Tree Code System Code
WHO-ATC B03BA04
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
WHO-VATC QB03BA04
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
DSLD 1612 (Number of products:7)
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
Code System Code Type Description
CAS
13870-90-1
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
RS_ITEM_NUM
1142195
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
FDA UNII
F0R1QK73KB
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
DAILYMED
F0R1QK73KB
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
ECHA (EC/EINECS)
237-627-6
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
NCI_THESAURUS
C169859
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID1046009
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
DRUG BANK
DB11191
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
RXCUI
21373
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY RxNorm
MERCK INDEX
m3705
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY Merck Index
NSC
757791
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
DRUG CENTRAL
4404
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
INN
1915
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
WIKIPEDIA
COBAMAMIDE
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
PUBCHEM
131635025
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
SMS_ID
100000084059
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
EVMPD
SUB06788MIG
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
CHEBI
18408
Created by admin on Sat Dec 16 20:10:39 GMT 2023 , Edited by admin on Sat Dec 16 20:10:39 GMT 2023
PRIMARY
Related Record Type Details
Structure of COBAMAMIDE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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