T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:35:23 GMT 2025` Edited by `admin` on `Tue Apr 01 20:35:23 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	F05Y5QQX44
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28

Common Name

English

CD-28

Preferred Name

English

CD28

Common Name

English

TP-44

Code

English

Code System Code Type Description

FDA UNII

F05Y5QQX44

Created by admin on Tue Apr 01 20:35:23 GMT 2025 , Edited by admin on Tue Apr 01 20:35:23 GMT 2025

PRIMARY

UNIPROT

P10747

Created by admin on Tue Apr 01 20:35:23 GMT 2025 , Edited by admin on Tue Apr 01 20:35:23 GMT 2025

PRIMARY

From	To
1_22	1_94
1_48	1_68

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_19
N	1_53
N	1_74
N	1_87
N	1_111

Related Record Type Details


					U00J02UY29

RELTECIMOD

INHIBITOR -> TARGET

Amount:


					CN0DU4MQE0

Ubletamig

LIGAND->TARGET

Amount:


					POO0DOD3AS

TGN-1412

AGONIST -> TARGET


					3Y7ANB3DKG

Efdelikofusp Alfa

ACTIVATOR -> TARGET

Comments:

GI101 has high binding affinity to CTLA4 acting as a decoy ligand, thereby enhancing the interaction between endogenous CD80 and CD28, leading to the activation of T cells

Interaction Type:

IN-VIVO

Amount:


					YG578HEY4V

T CELL TRANSACT, HUMAN

AGONIST -> TARGET

Amount:


					LCT264LTYE

LULIZUMAB PEGOL

INHIBITOR -> TARGET


					ZL3BS1J3LY

MACS GMP CD28 PURE

ACTIVATOR -> TARGET

Comments:

T cell activation can also be achieved by agonistic stimulation with the CD3 antibody binding to the TCR complex and can be enhanced by costimulation with CD28 antibody.


					MDY5U2QRN2

HUMAN CD28 HINGE AND TRANSMEMBRANE DOMAIN

DERIVATIVE -> PARENT

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_173] [1_191]				TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_171]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL