U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 13:21:43 UTC 2023
Edited
by admin
on Sat Dec 16 13:21:43 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
F05Y5QQX44
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
Common Name English
CD28
Common Name English
TP-44
Code English
CD-28
Code English
Code System Code Type Description
FDA UNII
F05Y5QQX44
Created by admin on Sat Dec 16 13:21:44 UTC 2023 , Edited by admin on Sat Dec 16 13:21:44 UTC 2023
PRIMARY
UNIPROT
P10747
Created by admin on Sat Dec 16 13:21:44 UTC 2023 , Edited by admin on Sat Dec 16 13:21:44 UTC 2023
PRIMARY
From To
1_22 1_94
1_48 1_68
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_19
N 1_53
N 1_74
N 1_87
N 1_111
Related Record Type Details
AGONIST -> TARGET
Superagonist LED TO CYTOKINE STORM
ACTIVATOR -> TARGET
GI101 has high binding affinity to CTLA4 acting as a decoy ligand, thereby enhancing the interaction between endogenous CD80 and CD28, leading to the activation of T cells
IN-VIVO
AGONIST -> TARGET
INHIBITOR -> TARGET
ACTIVATOR -> TARGET
T cell activation can also be achieved by agonistic stimulation with the CD3 antibody binding to the TCR complex and can be enhanced by costimulation with CD28 antibody.
DERIVATIVE -> PARENT
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL