Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H16 |
| Molecular Weight | 256.341 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C2C=CC=CC2=C(C)C3=C4C=CC=CC4=CC=C13
InChI
InChIKey=ARSRBNBHOADGJU-UHFFFAOYSA-N
InChI=1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
| Molecular Formula | C20H16 |
| Molecular Weight | 256.341 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity. | 1999 Dec 1 |
|
| Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. | 2001 |
|
| S-allylcysteine, a garlic constituent, inhibits 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. | 2001 |
|
| Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. | 2001 Aug 15 |
|
| Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha. II. | 2001 Dec |
|
| Chemoprevention of mammary, cervix and nervous system carcinogenesis in animals using cultured Panax ginseng drugs and preliminary clinical trials in patients with precancerous lesions of the esophagus and endometrium. | 2001 Dec |
|
| Chemopreventive efficacy of lycopene on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. | 2001 Dec |
|
| Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. | 2001 Dec |
|
| Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis. | 2001 Dec 1 |
|
| Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice. | 2001 Feb 1 |
|
| 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor. | 2001 Feb 2 |
|
| Mechanism of 7,12-dimethylbenz[a]anthracene-induced immunotoxicity: role of metabolic activation at the target organ. | 2001 Jul |
|
| Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats. | 2001 Jul 10 |
|
| Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice. | 2001 Jun 2 |
|
| Acceleration of mammary neoplasia in aromatase transgenic mice by 7,12-dimethylbenz[a]anthracene. | 2001 Jun 26 |
|
| Modulation of DMBA induced genotoxicity in bone marrow by quercetin during skin carcinogenesis. | 2001 Mar |
|
| Bowman-Birk protease inhibitor and its palmitic acid conjugate prevent 7,12-dimethylbenz[a]anthracene-induced transformation in cultured mouse mammary glands. | 2001 Mar 26 |
|
| The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis. | 2001 Mar 31 |
|
| Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands. | 2001 Mar-Apr |
|
| Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats. | 2001 May |
|
| Ras gene mutations in 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat sarcomas. | 2001 May 10 |
|
| Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata. | 2001 Nov |
|
| Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic. | 2001 Oct |
|
| New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. | 2001 Oct |
|
| Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. | 2001 Oct 15 |
|
| Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. | 2001 Sep |
|
| 7,12-Dimethylbenz[a]anthracene inhibition of steroid production in MA-10 mouse Leydig tumor cells is not directly linked to induction of CYP1B1. | 2001 Sep 15 |
|
| Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. | 2001 Sep 6 |
|
| Changes in expression of onco- and suppressor genes in peripheral leukocytes--as potential biomarkers of chemical carcinogenesis. | 2001 Sep-Oct |
|
| Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation. | 2002 Apr |
|
| Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene. | 2002 Apr |
|
| Effect of calorie restriction on mortality kinetics in inbred strains of mice following 7,12-dimethylbenz[a]anthracene treatment. | 2002 Apr |
|
| Tibolone and 5alpha-dihydrotestosterone alone or in combination with an antiandrogen in a rat breast tumour model. | 2002 Feb |
|
| Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses. | 2002 Jan 15 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 02:03:06 GMT 2023
by
admin
on
Sat Dec 16 02:03:06 GMT 2023
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| Record UNII |
F05B6S0395
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| Record Status |
Validated (UNII)
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| Record Version |
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254496
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m4527
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F05B6S0395
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7,12-DIMETHYLBENZ(A)ANTHRACENE
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408823
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