HYDROXYFASUDIL

OC1=C2C=CC=C(C2=CC=N1)S(=O)(=O)N3CCCNCC3

InChIKey=ZAVGJDAFCZAWSZ-UHFFFAOYSA-N

InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Rho-associated protein kinase 1 20 Target ID: CHEMBL3231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16141422	Inhibitor 8504		0.73 µM [IC50]
Rho-associated protein kinase 2 25 Target ID: CHEMBL2973 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16141422	Inhibitor 8504		0.72 µM [IC50]

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:56:51 GMT 2025` Edited by `admin` on `Tue Apr 01 16:56:51 GMT 2025`
Record UNII	EYH4AU7P63
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

HYDROXYFASUDIL

Common Name

English

HA-1100

Preferred Name

English

5-(1,4-DIAZEPAN-1-YLSULFONYL)-1(2H)-ISOQUINOLINONE

Systematic Name

English

1-((1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL)HEXAHYDRO-1H-1,4-DIAZEPINE

Systematic Name

English

1(2H)-ISOQUINOLINONE, 5-((HEXAHYDRO-1H-1,4-DIAZEPIN-1-YL)SULFONYL)-

Systematic Name

English

5-((1,4-DIAZEPAN-1-YL)SULFONYL)ISOQUINOLIN-1(2H)-ONE

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB04707