SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:06:26 GMT 2025` Edited by `admin` on `Wed Apr 02 02:06:26 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	EWR59AZK8G
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

HBSC II

Preferred Name

English

SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA

Common Name

English

SODIUM CHANNEL PROTEIN BRAIN II SUBUNIT ALPHA

Common Name

English

SODIUM CHANNEL PROTEIN TYPE II SUBUNIT ALPHA

Common Name

English

NAC2

Common Name

English

SCN2A2

Common Name

English

VOLTAGE-GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.2

Common Name

English

SCN2A1

Common Name

English

Code System Code Type Description

FDA UNII

EWR59AZK8G

Created by admin on Wed Apr 02 02:06:26 GMT 2025 , Edited by admin on Wed Apr 02 02:06:26 GMT 2025

PRIMARY

UNIPROT

Q99250

Created by admin on Wed Apr 02 02:06:26 GMT 2025 , Edited by admin on Wed Apr 02 02:06:26 GMT 2025

PRIMARY

PHAROS

Q99250

Created by admin on Wed Apr 02 02:06:26 GMT 2025 , Edited by admin on Wed Apr 02 02:06:26 GMT 2025

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_212
N	1_285
N	1_291
N	1_297
N	1_303
N	1_308
N	1_340
N	1_1368
N	1_1382
N	1_1393

Related Record Type Details


					Q72DWI2G4C

CROBENETINE

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Comments:

Binds preferentially to Na+ channels in their inactivated state. A high-affinity, stimulus-dependent blocker at the local anesthetic receptor site.

Interaction Type:

ALLOSTERIC

Qualification:

IC50

Amount:


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PF-05186462

WEAK INHIBITOR->TARGET

Amount:


					6158TKW0C5

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Qualification:

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Amount:


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PF-05089771

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Qualification:

Ki

Amount:


					U3H27498KS

LAMOTRIGINE

INHIBITOR -> TARGET

Comments:

Binds to inactivated state and prevents activation

Amount:


					R2GZD7LMYX

IRAMPANEL

INHIBITOR -> TARGET

Comments:

MAY ALSO BLOCK OTHER SODIUM CHANNELS

Amount:


					3KUM2721U9

TETRODOTOXIN

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					459384H98V

ZONISAMIDE

INHIBITOR -> TARGET


					6YRL8BWD9H

NEOSAXITOXIN

INHIBITOR -> TARGET

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_1943] [1_1963] [1_1966]		T		THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_4] [1_468] [1_471] [1_484] [1_526] [1_528] [1_531] [1_553] [1_554] [1_558] [1_573] [1_576] [1_589] [1_610] [1_623] [1_686] [1_687] [1_721] [1_1506] [1_1971]		S		DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL