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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H28FN7O
Molecular Weight 460.5353
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMA-107 C-11

SMILES

CC1=C(N=C2C=CC=CC2=N1)C3=NN4C(=C3)N=C(C=C4N([11CH3])C5CCOCC5)N6CC[C@@H](F)C6

InChI

InChIKey=XJHYZPHNGDXRJW-PIMHITSUSA-N
InChI=1S/C25H28FN7O/c1-16-25(28-20-6-4-3-5-19(20)27-16)21-13-23-29-22(32-10-7-17(26)15-32)14-24(33(23)30-21)31(2)18-8-11-34-12-9-18/h3-6,13-14,17-18H,7-12,15H2,1-2H3/t17-/m1/s1/i2-1

HIDE SMILES / InChI

Molecular Formula C25H28FN7O
Molecular Weight 460.5353
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 12:04:13 UTC 2023
Edited
by admin
on Sat Dec 16 12:04:13 UTC 2023
Record UNII
EUS54KI9L5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IMA-107 C-11
Code English
(11C)IMA-107
Common Name English
5-((3R)-3-FLUOROPYRROLIDIN-1-YL)-N-(11C)METHYL-2-(3-METHYLQUINOXALIN-2-YL)-N-TETRAHYDROPYRAN-4-YL-PYRAZOLO(1,5-A)PYRIMIDIN-7-AMINE
Systematic Name English
Code System Code Type Description
PUBCHEM
118727099
Created by admin on Sat Dec 16 12:04:13 UTC 2023 , Edited by admin on Sat Dec 16 12:04:13 UTC 2023
PRIMARY
FDA UNII
EUS54KI9L5
Created by admin on Sat Dec 16 12:04:13 UTC 2023 , Edited by admin on Sat Dec 16 12:04:13 UTC 2023
PRIMARY
CAS
1810802-70-0
Created by admin on Sat Dec 16 12:04:13 UTC 2023 , Edited by admin on Sat Dec 16 12:04:13 UTC 2023
PRIMARY
Related Record Type Details
TARGET->RADIOLIGAND
BINDING
IC50
NON-LABELED -> LABELED
Related Record Type Details
ACTIVE MOIETY
Results: PET images and TACs showed regional heterogeneity, reflective of the known distribution of PDE10A. Kinetic modelling showed the superiority of the 2TC over the 1TC model (assessed visually and via AIC). SRTM also produced acceptable model fits. 2TC fits produced well-determined VT estimates (COV<10%) for 89/91 TACs. SRTM fits produced well-determined BPND estimates (COV<10%) for 85/91 TACs (remaining 6/91 all SN, all COV<20%). Time stability analysis supported a reduction in scan duration to 60 min. Inter-subject variability was good, with mean COV (n=7) for baseline scans of VT2TC: 21%, BPND2TC: 21%, BPNDSRTM: 18%. Test-retest variability (n=4) was VT2TC: 12%, BPND2TC: 15%, BPNDSRTM: 12%. There was an excellent correlation between the 2TC- and SRTM-derived BPND (r2>0.99 p<<0.05). Conclusions: Kinetic parameters for (11C)-IMA107 are well-estimated using 2TC and SRTM. Further studies will fully validate the use of cerebellum as reference region.