U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 23:14:40 GMT 2025
Edited
by admin
on Tue Apr 01 23:14:40 GMT 2025
Protein Type MONOCLONAL ANTIBODY FUSION PROTEIN
Protein Sub Type IGG1
Sequence Origin CAMEL
Sequence Type COMPLETE
Record UNII
ES1M06M6QH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ASC-22
Preferred Name English
ENVAFOLIMAB
INN  
Official Name English
KN-035
Code English
ASC22
Code English
ANTI-PD-L1 MONOCLONAL ANTIBODY KN035
Common Name English
envafolimab [INN]
Common Name English
IMMUNOGLOBULIN G, ANTI-(HUMAN PROGRAMMED DEATH LIGAND 1) (HUMAN-CAMELIDAE MONOCLONAL KN-035 .GAMMA.-CHAIN VARIABLE REGION FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN MONOCLONAL KN-035 .GAMMA.1-CHAIN FC FRAGMENT), DIMER
Common Name English
KN035
Code English
Envafolimab [WHO-DD]
Common Name English
IMMUNOGLOBULIN VH-H-CH2-CH3 GAMMA1 CHAIN DIMER, ANTI-(HOMO SAPIENS CD274 (PROGRAMMED DEATH LIGAND 1, PDL1, PD-L1, B7 HOMOLOG 1, B7H1)), MONOCLONAL ANTIBODYGAMMA1 HEAVY CHAIN VH-H-CH2-CH3 (1-360) (VH (VICUGNA PACOS IGHV3-3*01 (80.6%)-(IGHD)-IGHJ5*01 (92.3
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C128057
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
FDA ORPHAN DRUG 745320
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
NCI_THESAURUS C129822
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
FDA ORPHAN DRUG 718819
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
Code System Code Type Description
FDA UNII
ES1M06M6QH
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
PRIMARY
CAS
2102192-68-5
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
PRIMARY
NCI_THESAURUS
C129714
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
PRIMARY
SMS_ID
300000005900
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
PRIMARY
INN
10930
Created by admin on Tue Apr 01 23:14:40 GMT 2025 , Edited by admin on Tue Apr 01 23:14:40 GMT 2025
PRIMARY
From To
1_22 1_96
1_33 1_106
1_139 2_139
1_142 2_142
1_174 1_234
1_280 1_338
2_22 2_96
2_33 2_106
2_174 2_234
2_280 2_338
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_210
N 2_210
Related Record Type Details
PROGRAMMED CELL DEATH 1 LIGAND 1
TARGET -> INHIBITOR
Related Record Type Details
ENVAFOLIMAB
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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