ENVAFOLIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:21:00 GMT 2023` Edited by `admin` on `Sat Dec 16 14:21:00 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY FUSION PROTEIN
Protein Sub Type	IGG1
Sequence Origin	CAMEL
Sequence Type	COMPLETE
Record UNII	ES1M06M6QH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ENVAFOLIMAB

Official Name

English

KN-035

Code

English

ASC22

Code

English

ANTI-PD-L1 MONOCLONAL ANTIBODY KN035

Common Name

English

envafolimab [INN]

Common Name

English

IMMUNOGLOBULIN G, ANTI-(HUMAN PROGRAMMED DEATH LIGAND 1) (HUMAN-CAMELIDAE MONOCLONAL KN-035 .GAMMA.-CHAIN VARIABLE REGION FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN MONOCLONAL KN-035 .GAMMA.1-CHAIN FC FRAGMENT), DIMER

Common Name

English

KN035

Code

English

ASC-22

Code

English

Envafolimab [WHO-DD]

Common Name

English

IMMUNOGLOBULIN VH-H-CH2-CH3 GAMMA1 CHAIN DIMER, ANTI-(HOMO SAPIENS CD274 (PROGRAMMED DEATH LIGAND 1, PDL1, PD-L1, B7 HOMOLOG 1, B7H1)), MONOCLONAL ANTIBODYGAMMA1 HEAVY CHAIN VH-H-CH2-CH3 (1-360) (VH (VICUGNA PACOS IGHV3-3*01 (80.6%)-(IGHD)-IGHJ5*01 (92.3

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C128057

Created by admin on Sat Dec 16 14:21:00 GMT 2023 , Edited by admin on Sat Dec 16 14:21:00 GMT 2023

FDA ORPHAN DRUG

745320

Created by admin on Sat Dec 16 14:21:00 GMT 2023 , Edited by admin on Sat Dec 16 14:21:00 GMT 2023

NCI_THESAURUS

C129822

Created by admin on Sat Dec 16 14:21:00 GMT 2023 , Edited by admin on Sat Dec 16 14:21:00 GMT 2023

FDA ORPHAN DRUG

718819

Created by admin on Sat Dec 16 14:21:00 GMT 2023 , Edited by admin on Sat Dec 16 14:21:00 GMT 2023

Code System Code Type Description

FDA UNII

ES1M06M6QH

Created by admin on Sat Dec 16 14:21:00 GMT 2023 , Edited by admin on Sat Dec 16 14:21:00 GMT 2023

PRIMARY

CAS

2102192-68-5

Created by admin on Sat Dec 16 14:21:00 GMT 2023 , Edited by admin on Sat Dec 16 14:21:00 GMT 2023

PRIMARY

NCI_THESAURUS

C129714

Created by admin on Sat Dec 16 14:21:00 GMT 2023 , Edited by admin on Sat Dec 16 14:21:00 GMT 2023

PRIMARY

INN

10930

Created by admin on Sat Dec 16 14:21:00 GMT 2023 , Edited by admin on Sat Dec 16 14:21:00 GMT 2023

PRIMARY

From	To
1_22	1_96
1_33	1_106
1_139	2_139
1_142	2_142
1_174	1_234
1_280	1_338
2_22	2_96
2_33	2_106
2_174	2_234
2_280	2_338

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_210
N	2_210

Related Record Type Details


					L4766ELH5T

PROGRAMMED CELL DEATH 1 LIGAND 1

TARGET -> INHIBITOR

Related Record Type Details


					ES1M06M6QH

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL