FLUINDIONE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H9FO2
Molecular Weight	240.2292
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C2C(=O)C3=C(C=CC=C3)C2=O

InChI

InChIKey=NASXCEITKQITLD-UHFFFAOYSA-N

InChI=1S/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H

HIDE SMILES / InChI

Molecular Formula	C15H9FO2
Molecular Weight	240.2292
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9465843 | https://www.onmeda.fr/medicament/previscan-93348413.html

Fluindione under the brand name Previscan, an oral anticoagulant, belongs to the vitamin K antagonist class and widely used in France. This drug is indicated to treat the thromboembolic diseases, the deep venous thrombosis, and pulmonary embolism.

Approval Year

PubMed

Title	Date	PubMed
Immunoallergic adverse effects of fluindione.	2010-11	21284358
[Usefulness of JAK2 mutation assessment in recurrent deep venous thrombosis].	2010-07	20362361
[Glycopeptide-induced cutaneous adverse reaction].	2010-05	20470913
Validation of a new liquid chromatography- tandem mass spectrometry ion-trap technique for the simultaneous determination of thirteen anticoagulant rodenticides, drugs, or natural products.	2010-03	20223102
[Thrombosis of the inferior vena cava revealing primary antiphospholipid syndrome: a case report].	2010-02	19969435
Ischemic Stroke of the Artery of Percheron with Normal Initial MRI: A Case Report.	2010	20300550
Budd-Chiari syndrome as a vascular complication of amebic liver abscess.	2009-11	19861608
[Inefficacy of vitamin K antagonists in an human immunodeficiency virus seropositive patient taking nevirapine].	2009-11	19375272
Use the INN to avoid confusion between drugs.	2009-10	19882793
[Severe overdose in vitamin K antagonist secondary to grapefruit juice absorption].	2009-10	19766437
Safety and efficacy of fondaparinux as an adjunctive treatment to thrombolysis in patients with high and intermediate risk pulmonary embolism.	2009-10	18953636
Catheter related venous thrombosis with cooling and warming catheters: two case reports.	2009-09-08	20184700
[Acute immuno-allergic interstitial nephritis after treatment with fluindione. Seven cases].	2009-07	19357010
[Anticoagulation clinics for outpatients: a 5-year experience].	2009-07	19299042
A new VKORC1 mutation leading to an isolated resistance to fluindione.	2009-06	19344422
[Multidrug intoxication].	2009-03-20	19297297
[Liver infarcts with early HELLP syndrome and probable catastrophic antiphospholipid syndrome].	2009-03	19131145
[Necrotizing folliculitis in Behçet's disease].	2009-03	18635291
Interactions between herbal medicines and prescribed drugs: an updated systematic review.	2009	19719333
Self-control of long-term oral anticoagulation using a point-of-care device.	2008-12-09	19059561
[Prospective study of oral anticoagulation control in 110 very elderly hospitalized patients and of risk factors for poor control].	2008-12	18644323
[Hepatic and renal toxicity to fluindione (Previscan)].	2008-10	18818035
[Acute interstitial nephritis of fluindione: about three cases].	2008-10	18417438
Comparison of INR stability between self-monitoring and standard laboratory method: preliminary results of a prospective study in 67 mechanical heart valve patients.	2008-07-02	19059570
[Fluindione-induced acute generalised exanthematous pustulosis confirmed by patch testing].	2008-04	18420077
Severe hemorrhagic syndrome due to similarity of drug names.	2008-03	18249310
Garlic (Allium sativum L.): adverse effects and drug interactions in humans.	2007-11	17918162
Potentiation of fluindione or warfarin by dexamethasone in multiple myeloma and AL amyloidosis.	2007-10	17692552
Conservative treatment of spontaneous and isolated dissection of mesenteric arteries.	2007-07-30	19875008
[Liver toxicity associated with oral anticoagulant treatment: report of two cases].	2007-07-25	17646791
[Advice for patients taking oral anticoagulants (coumadin or Previscan)].	2007-04-15	17626322
Descriptive analysis of the process and quality of oral anticoagulation management in real-life practice in patients with chronic non-valvular atrial fibrillation: the international study of anticoagulation management (ISAM).	2007-04	17221328
Management of atrial fibrillation.	2007	17583181
Can cryoglobulins interfere with the measurement of IgM antiphosphatidylethanolamine antibodies by ELISA?	2007	16766022
Acute immuno-allergic interstitial nephritis caused by fluindione.	2006-12	17176918
[Mesenteric hematoma: Unusual complication of a long term oral anticoagulation therapy].	2006-11	16712769
[Unusual haemostasis disorder in a seriously burned patient].	2006-10	17005353
Vitamin K antagonists and pregnancy outcome. A multi-centre prospective study.	2006-06	16732373
Immuno-allergic interstitial nephritis related to fluindione: first biopsy proven cases.	2006-01	16221711
[Hypersensitivity to fluindione (Previscan). Positive skin patch tests].	2005-12	16446646
Interaction between paracetamol and oral anticoagulants.	2005-12	16204376
Can colchicine potentiate the anticoagulant effect of fluindione?	2005-08	16007421
Treatment of left ventricular thrombi with a low molecular weight heparin.	2005-02-15	15686785
Management of oral anticoagulant in clinical practice: a retrospective study of 187 patients.	2004-12	15699536
Personalized versus non-personalized computerized decision support system to increase therapeutic quality control of oral anticoagulant therapy: an alternating time series analysis.	2004-09-29	15456515
[Spontaneous muscular haematomas in hemiplegic patients receiving anticoagulation therapy].	2004-07	15247856
Oral anticoagulant drug interactions with statins: case report of fluvastatin and review of the literature.	2004-02	14998226
Aspirin--anticoagulant combination in patients with non valvular atrial fibrillation commentary on the FFAACS study results.	2003-12	15071257
[A necrotic plaque on the thigh].	2003-11	14724545
[Thrombocytopenia and tubulo-interstitial nephropathy associated with fluindione].	1991-09-01	1754986

Sample Use Guides

In Vivo Use Guide

20 mg at the beginning with 5 mg increments

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:27:34 GMT 2025` Edited by `admin` on `Wed Apr 02 09:27:34 GMT 2025`
Record UNII	EQ35YMS20Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PREVISCCAN

Preferred Name

English

FLUINDIONE

Official Name

English

FLUINDIONE [MART.]

Common Name

English

2-(P-FLUOROPHENYL)-1,3-INDANDIONE

Common Name

English

Fluindione [WHO-DD]

Common Name

English

fluindione [INN]

Common Name

English

FLUINDIONE [MI]

Common Name

English

Classification Tree Code System Code

WHO-ATC

B01AA12