HEXAMETHYLCYCLOTRISILOXANE

Possibly Marketed Outside US

First approved in 2016

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H18O3Si3
Molecular Weight	222.4618
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1

InChI

InChIKey=HTDJPCNNEPUOOQ-UHFFFAOYSA-N

InChI=1S/C6H18O3Si3/c1-10(2)7-11(3,4)9-12(5,6)8-10/h1-6H3

HIDE SMILES / InChI

Molecular Formula	C6H18O3Si3
Molecular Weight	222.4618
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Cosmetic camouflage in vitiligo.	2010-11-11	21063508
Update on treatments for head lice.	2010-10	20855348
A new two-phase dimeticone pediculicide shows high efficacy in a comparative bioassay.	2009-12-14	20003435
Simultaneous chain-growth and step-growth polymerization-a new route to cyclic polymers.	2009-08-18	21638394
Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.	2009-08	19361861
Update on treatments for head lice.	2009-05	19423676
The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis.	2009-02-20	19232080
Underarm antiperspirants/deodorants and breast cancer.	2009	20030880
A mechanistic study of cyclic siloxane pyrolyses at low pressures.	2008-12-07	19015791
A novel metered dose transdermal spray formulation for oxybutynin.	2008-11	21369433
Clinical efficacy evaluation of a novel barrier protection cream.	2008-10	19202673
Clinical safety evaluation of a novel barrier protection cream.	2008-10	19202672
Decomposition of hexamethylcyclotrisiloxane over solid oxides.	2008-08	18602661
Skin protection creams in medical settings: successful or evil?	2008-07-25	18655702
Density functional theory calculation of (29)Si NMR chemical shifts of organosiloxanes.	2005-07-21	16852704
Study of sensory properties of emollients used in cosmetics and their correlation with physicochemical properties.	2005-02-28	16116522
In vitro measurement of conformational stability of fibrinogen adsorbed on siloxane.	2005-01-11	15638502
Effects of silicone emulsifiers on in vitro skin permeation of sunscreens from cosmetic emulsions.	2004-10-15	15645107
Stabilization of emulsions using polymeric surfactants based on inulin.	2004-05-20	15072943
Superoxide-stable ionic liquids: new and efficient media for electrosynthesis of functional siloxanes.	2004-03-21	15010775
Texture optimization of water-in-oil emulsions.	2004	15202571
Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.	2003-11-01	14575643
Compound allergy to Vea Oil.	2003-10	14996082
O/W microemulsion as a vehicle for sunscreens.	2003-06-16	14605687
Migration of antioxidant additives from various polyolefinic plastics into oleaginous vehicles.	2003-05-12	12711176
Evaluation of matrix-assisted laser desorption ionization mass spectrometry for studying the sec-butyllithium and n-butyllithium initiated ring-opening polymerization of hexamethylcyclotrisiloxane (D3).	2003-02	12586458
Effect of occlusion on the percutaneous penetration of linoleic acid and glycerol.	2002-12-05	12433444
Deoligomerization of siloxanes with dimethyl carbonate over solid-base catalysts.	2001-09-21	12240340
Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.	2001-02-01	11217769

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:58:53 GMT 2025` Edited by `admin` on `Mon Mar 31 19:58:53 GMT 2025`
Record UNII	EPV75L8O0R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEXAMETHYLCYCLOTRISILOXANE

Systematic Name

English

CYCLOTRISILOXANE, HEXAMETHYL-

Preferred Name

English

Code System Code Type Description

WIKIPEDIA

Hexamethylcyclotrisiloxane