HEXAMETHYLCYCLOTRISILOXANE

Possibly Marketed Outside US

First approved in 2016

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H18O3Si3
Molecular Weight	222.4618
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1

InChI

InChIKey=HTDJPCNNEPUOOQ-UHFFFAOYSA-N

InChI=1S/C6H18O3Si3/c1-10(2)7-11(3,4)9-12(5,6)8-10/h1-6H3

HIDE SMILES / InChI

Molecular Formula	C6H18O3Si3
Molecular Weight	222.4618
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.	2001 Feb 1	11217769
Deoligomerization of siloxanes with dimethyl carbonate over solid-base catalysts.	2001 Sep 21	12240340
Effect of occlusion on the percutaneous penetration of linoleic acid and glycerol.	2002 Dec 5	12433444
Evaluation of matrix-assisted laser desorption ionization mass spectrometry for studying the sec-butyllithium and n-butyllithium initiated ring-opening polymerization of hexamethylcyclotrisiloxane (D3).	2003 Feb	12586458
Migration of antioxidant additives from various polyolefinic plastics into oleaginous vehicles.	2003 May 12	12711176
Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.	2003 Nov 1	14575643
Compound allergy to Vea Oil.	2003 Oct	14996082
O/W microemulsion as a vehicle for sunscreens.	2003 Sep-Oct	14605687
Texture optimization of water-in-oil emulsions.	2004	15202571
Superoxide-stable ionic liquids: new and efficient media for electrosynthesis of functional siloxanes.	2004 Mar 21	15010775
Stabilization of emulsions using polymeric surfactants based on inulin.	2004 May 20	15072943
Effects of silicone emulsifiers on in vitro skin permeation of sunscreens from cosmetic emulsions.	2004 Nov-Dec	15645107
In vitro measurement of conformational stability of fibrinogen adsorbed on siloxane.	2005 Jan-Feb	15638502
Density functional theory calculation of (29)Si NMR chemical shifts of organosiloxanes.	2005 Jul 21	16852704
Study of sensory properties of emollients used in cosmetics and their correlation with physicochemical properties.	2005 May-Jun	16116522
Decomposition of hexamethylcyclotrisiloxane over solid oxides.	2008 Aug	18602661
A mechanistic study of cyclic siloxane pyrolyses at low pressures.	2008 Dec 7	19015791
Skin protection creams in medical settings: successful or evil?	2008 Jul 25	18655702
A novel metered dose transdermal spray formulation for oxybutynin.	2008 Nov	21369433
Clinical efficacy evaluation of a novel barrier protection cream.	2008 Oct	19202673
Clinical safety evaluation of a novel barrier protection cream.	2008 Oct	19202672
Underarm antiperspirants/deodorants and breast cancer.	2009	20030880
Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.	2009 Aug	19361861
Simultaneous chain-growth and step-growth polymerization-a new route to cyclic polymers.	2009 Aug 18	21638394
A new two-phase dimeticone pediculicide shows high efficacy in a comparative bioassay.	2009 Dec 14	20003435
The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis.	2009 Feb 20	19232080
Update on treatments for head lice.	2009 May	19423676
Cosmetic camouflage in vitiligo.	2010 Jul-Sep	21063508
Update on treatments for head lice.	2010 Oct	20855348

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:51:09 GMT 2023` Edited by `admin` on `Fri Dec 15 19:51:09 GMT 2023`
Record UNII	EPV75L8O0R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEXAMETHYLCYCLOTRISILOXANE

Systematic Name

English

CYCLOTRISILOXANE, HEXAMETHYL-

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

Hexamethylcyclotrisiloxane