FORFENIMEX

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C9H11NO4
Molecular Weight	197.1879
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@H](C(O)=O)C1=CC=C(CO)C(O)=C1

InChI

InChIKey=JRBXPUUAYKCCLQ-QMMMGPOBSA-N

InChI=1S/C9H11NO4/c10-8(9(13)14)5-1-2-6(4-11)7(12)3-5/h1-3,8,11-12H,4,10H2,(H,13,14)/t8-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C9H11NO4
Molecular Weight	197.1879
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3034847 | https://www.ncbi.nlm.nih.gov/pubmed/15887016

Forfenimex (also known as forphenicinol), a low molecular weight immunomodifier was studied as an antineoplastic agent. Preclinical experiments in vitro have shown that forfenimex enhanced the antitumor effects of cyclophosphamide in a model of squamous cell carcinoma. Experiments on rodents have revealed that this compound possessed protective effect against P. aeruginosa infection. This influence achieved due to macrophage activation followed by the enhancement of the bactericidal activity of polymorphonuclear cells (PMN).

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
macrophage activation involved in immune response 3 Target ID: GO:0002281 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3034847	Activator 1447

PubMed

Title	Date	PubMed
Effect of forphenicinol, a low molecular weight immunomodifier, on the growth of and the immune responses to murine lymphoma EL4.	1987-02	3559627
Antitumor effect of forphenicinol, a low molecular weight immunomodifier, in combination with surgery on Meth A fibrosarcoma, Lewis lung carcinoma, and adenocarcinoma 755.	1986-04	3710915
Effect of forphenicinol on the production of Ia-positive macrophages in mice with or without L1210 leukemia and on the growth of L1210 in immunized mice.	1986-04	3458691
Studies on effects of forphenicinol on immune responses.	1982-08	7142005

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:33:35 GMT 2025` Edited by `admin` on `Mon Mar 31 18:33:35 GMT 2025`
Record UNII	EL461OY152
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(+)-(S)-2-(.ALPHA.,3-DIHYDROXY-P-TOLYL)GLYCINE

Preferred Name

English

FORFENIMEX

Official Name

English

forfenimex [INN]

Common Name

English

FORFENIMEX [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2139