SCRIPTAID

ONC(=O)CCCCCN1C(=O)C2=CC=CC3=C2C(=CC=C3)C1=O

InChIKey=JTDYUFSDZATMKU-UHFFFAOYSA-N

InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Histone deacetylase 6 27 Target ID: CHEMBL1865 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19966789	Inhibitor 8297	10.0 nM [IC50]
Histone deacetylase 3 35 Target ID: CHEMBL1829 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19966789	Inhibitor 8297	100.0 nM [IC50]
Histone deacetylase 1 51 Target ID: CHEMBL325 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19966789	Inhibitor 8297	200.0 nM [IC50]

PubMed

Title	Date	PubMed
A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.	2000 Jun 15	10866300
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.	2010 Jan	19966789

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:40:07 GMT 2023` Edited by `admin` on `Sat Dec 16 10:40:07 GMT 2023`
Record UNII	EJQ8CD8BSV
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

SCRIPTAID

Common Name

English

1H-BENZ(DE)ISOQUINOLINE-2(3H)-HEXANAMIDE, N-HYDROXY-1,3-DIOXO-

Common Name

English

N-HYDROXY-1,3-DIOXO-1H-BENZ(DE)ISOQUINOLINE-2(3H)-HEXAN AMIDE

Common Name

English

Code System Code Type Description

WIKIPEDIA

Scriptaid