HT-2157, (Z)-

Investigational

FC(F)(F)C1=CC(=CC=C1)\N=C2/C(=O)N(C3=CC=CC=C23)C4=CC=CC=C4

InChIKey=TXCGMRVPXUBHAL-PLRJNAJWSA-N

InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19-

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Galanin receptor 3 2 Target ID: CHEMBL2731 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16287967	Antagonist 2849		17.44 nM [Ki]

PubMed

Title	Date	PubMed
The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats.	2011-01-17	20736033
Involvement of galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity.	2007-09-01	17627995
Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.	2006-08-01	16730981
3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.	2006-06-29	16789730
Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders.	2006	16863269
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.	2005-11-29	16287967

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:05:11 GMT 2025` Edited by `admin` on `Mon Mar 31 18:05:11 GMT 2025`
Record UNII	EH5R4IAX6Q
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

HT-2157, (Z)-

Code

English

SNAP-37889, (Z)-

Preferred Name

English

2H-INDOL-2-ONE, 1,3-DIHYDRO-1-PHENYL-3-((3-(TRIFLUOROMETHYL)PHENYL)IMINO)-, (3Z)-

Systematic Name

English

(Z)-1-PHENYL-3-((3-(TRIFLUOROMETHYL)PHENYL)IMINO)-1,3-DIHYDRO-2H-INDOL-2-ONE

Systematic Name

English

Code System Code Type Description

FDA UNII

EH5R4IAX6Q

Created by admin on Mon Mar 31 18:05:11 GMT 2025 , Edited by admin on Mon Mar 31 18:05:11 GMT 2025

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