NEDOSIRAN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:56:12 GMT 2023` Edited by `admin` on `Sat Dec 16 14:56:12 GMT 2023`
Nucleic Acid Type	RNAI
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	EGR9KYM536
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NEDOSIRAN SODIUM

Official Name

English

RIVFLOZA

Brand Name

English

DCR-PHXC

Code

English

NEDOSIRAN SODIUM [USAN]

Official Name

English

RNA, (AM-SP-(2'-DEOXY-2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)U-GM-UM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)C-UM-GM-AM-GM-CM-AM-GM-CM-CM

Common Name

English

Code System Code Type Description

USAN

GH-113

Created by admin on Sat Dec 16 14:56:12 GMT 2023 , Edited by admin on Sat Dec 16 14:56:12 GMT 2023

PRIMARY

FDA UNII

EGR9KYM536

Created by admin on Sat Dec 16 14:56:12 GMT 2023 , Edited by admin on Sat Dec 16 14:56:12 GMT 2023

PRIMARY

CAS

2247026-22-6

Created by admin on Sat Dec 16 14:56:12 GMT 2023 , Edited by admin on Sat Dec 16 14:56:12 GMT 2023

PRIMARY

NCI_THESAURUS

C175829

Created by admin on Sat Dec 16 14:56:12 GMT 2023 , Edited by admin on Sat Dec 16 14:56:12 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1;1_6;1_8;1_11-1_13;1_15;1_17;1_19-1_22;2_1-2_2;2_4;2_6-2_7;2_12;2_14;2_16;2_18-2_26;2_31-2_36	35 / 58
2'-Fluoro-Ribose	1_2-1_5;1_7;1_9-1_10;1_14;1_16;1_18;2_3;2_5;2_8-2_11;2_13;2_15;2_17	19 / 58
D-Ribose (RNA)	2_27-2_30	4 / 58

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_1-1_3;1_20-1_21;2_1	6 / 56
	1_4-1_19;2_2-2_35	50 / 56

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					4IDZ3J79QQ

L-LACTATE DEHYDROGENASE A CHAIN

INHIBITOR OF EXPRESSION->TARGET

Amount:


					4IDZ3J79QQ

L-LACTATE DEHYDROGENASE A CHAIN

TARGET->INHIBITOR OF EXPRESSION

Related Record Type Details


					13U9R5J3WL

NEDOSIRAN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_1]	5'-TERMINUS		UNSPECIFIED SUBSTANCE	55513d6d (not in database)
MOIETY			Amount:	SODIUM CATION	LYR4M0NH37
NUCLEOSIDE_SUBSTITUTION	[2_27]	SITE_SPECIFIC		UNSPECIFIED SUBSTANCE	4b489b28 (not in database)
NUCLEOSIDE_SUBSTITUTION	[2_28] [2_29] [2_30]	SITE_SPECIFIC		UNSPECIFIED SUBSTANCE	3a625511 (not in database)