Opelkibart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:52:50 GMT 2025` Edited by `admin` on `Wed Apr 02 12:52:50 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	EAM2YZ4YT4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Opelkibart

Official Name

English

M-1224

Preferred Name

English

opelkibart [INN]

Common Name

English

Immunoglobulin G1 [240-alanine,241-alanine,271-cysteine,441-alanine], anti-(human c-Kit protein) (human monoclonal M-1224 ?1-chain), disulfide with human monoclonal M-1224 ?-chain, dimer

Common Name

English

M1224

Code

English

Code System Code Type Description

NCI_THESAURUS

C203076

Created by admin on Wed Apr 02 12:52:50 GMT 2025 , Edited by admin on Wed Apr 02 12:52:50 GMT 2025

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INN

12810

Created by admin on Wed Apr 02 12:52:50 GMT 2025 , Edited by admin on Wed Apr 02 12:52:50 GMT 2025

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FDA UNII

EAM2YZ4YT4

Created by admin on Wed Apr 02 12:52:50 GMT 2025 , Edited by admin on Wed Apr 02 12:52:50 GMT 2025

PRIMARY

CAS

2771389-44-5

Created by admin on Wed Apr 02 12:52:50 GMT 2025 , Edited by admin on Wed Apr 02 12:52:50 GMT 2025

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SMS_ID

300000051891

Created by admin on Wed Apr 02 12:52:50 GMT 2025 , Edited by admin on Wed Apr 02 12:52:50 GMT 2025

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From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_373	2_431
2_267	2_327
2_226	4_214
2_150	2_206
2_22	2_96
1_373	1_431
1_267	1_327
1_235	2_235
1_232	2_232
1_226	3_214
1_150	1_206
1_22	1_96

Glycosylation Link Type	Site
N	1_303
N	2_303

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_453] [2_453]	SITE_SPECIFIC		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL