NUCLEOLIN

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:23:16 GMT 2025` Edited by `admin` on `Wed Apr 02 11:23:16 GMT 2025`
Protein Type	NUCLEOLAR PROTEIN
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	EA6MNS8JXJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NUCLEOLIN

Common Name

English

PROTEIN C23

Preferred Name

English

Code System Code Type Description

UNIPROT

P19338

Created by admin on Wed Apr 02 11:23:16 GMT 2025 , Edited by admin on Wed Apr 02 11:23:16 GMT 2025

PRIMARY

FDA UNII

EA6MNS8JXJ

Created by admin on Wed Apr 02 11:23:16 GMT 2025 , Edited by admin on Wed Apr 02 11:23:16 GMT 2025

PRIMARY

Related Record Type Details


					8M31J5031Q

QUARFLOXIN

INHIBITOR -> TARGET

Comments:

Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_8] [1_14] [1_15] [1_95] [1_102] [1_108] [1_115] [1_123] [1_317] [1_347] [1_376] [1_397] [1_402] [1_426] [1_443] [1_466] [1_476] [1_512] [1_520] [1_571] [1_576] [1_645]	SITE_SPECIFIC	N6-ACETYLLYSINE	470AD5VY1X
AMINO_ACID_SUBSTITUTION	[1_58] [1_75] [1_83] [1_91] [1_98] [1_105] [1_112] [1_120] [1_213] [1_300] [1_366] [1_404]	SITE_SPECIFIC	THREONINE PHOSPHATE	3L4WX7B1EI
AMINO_ACID_SUBSTITUTION	[1_655] [1_659] [1_665] [1_669] [1_672] [1_678] [1_680] [1_686] [1_690] [1_693]	SITE_SPECIFIC	N,N-DIMETHYLARGININE	63CV1GEK3Y
AMINO_ACID_SUBSTITUTION	[1_27] [1_33] [1_40] [1_41] [1_66] [1_144] [1_152] [1_183] [1_205] [1_355] [1_457] [1_459] [1_562] [1_579] [1_590] [1_618]	SITE_SPECIFIC	DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL