Details
| Stereochemistry | MIXED |
| Molecular Formula | C18H33O3.Na |
| Molecular Weight | 320.4426 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCCCCC[C@H]1CCC(O)[C@@H]1CCCCCCC([O-])=O
InChI
InChIKey=ALNUHUMOGUVHIO-XXJNWDAFSA-M
InChI=1S/C18H34O3.Na/c1-2-3-4-7-10-15-13-14-17(19)16(15)11-8-5-6-9-12-18(20)21;/h15-17,19H,2-14H2,1H3,(H,20,21);/q;+1/p-1/t15-,16+,17?;/m0./s1
| Molecular Formula | C18H33O3 |
| Molecular Weight | 297.4528 |
| Charge | -1 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Rosaprostol is an antiulcer drug. This compound acts on the mucosal barrier in the stomach, preventing a drop in pH. More specifically, rosaprostol exhibits gastric antisecretory activity and cytoprotective action. Importantly, it does not have the undesired side effects (such as diarrhea and uterine stimulation) of other prostanoids. Rosaprostol was found to antagonize gastric acid output induced by NSAID administration and to prevent and treat the digestive disorders that resulted from taking NSAIDs. Furthermore, symptoms in patients with gastritis disappeared after administration of rosaprostol, and the drug was well-tolerated. Positive effects of rosaprostol were also reported in patients with duodenal ulcer. Several stereoisomers of rosaprostol have been synthesized.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway. | 2009-06 |
|
| Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa on necrotizing agents-induced gastric injury in experimental animals. | 2008-07 |
|
| Effects of anoxia and hypoxia on amyloid precursor protein processing in cerebral microvascular smooth muscle cells. | 2006-06 |
Patents
| Substance Class |
Chemical
Created
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admin
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Edited
Mon Mar 31 18:44:10 GMT 2025
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Mon Mar 31 18:44:10 GMT 2025
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| Record UNII |
E9ZT7G582H
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