DONETIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H25N5O3S
Molecular Weight	415.509
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CC1=CC=C(CSCCNC2=NC(=O)C(CC3=CC(=O)NC=C3)=CN2)O1

InChI

InChIKey=MURUHMTVTKOWBY-UHFFFAOYSA-N

InChI=1S/C20H25N5O3S/c1-25(2)12-16-3-4-17(28-16)13-29-8-7-22-20-23-11-15(19(27)24-20)9-14-5-6-21-18(26)10-14/h3-6,10-11H,7-9,12-13H2,1-2H3,(H,21,26)(H2,22,23,24,27)

HIDE SMILES / InChI

Molecular Formula	C20H25N5O3S
Molecular Weight	415.509
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2469790 | DOI: 10.1016/0223-5234(93)90091-R | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 466, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Donetidine is a potent and long acting histamine H2-receptor antagonist with no H1-receptor antagonist activity. It is a highly basic drug with several amine groups. Donetidine stimulates the release of histamine when given by rapid intravenous infusion to dogs. Symptoms such as vasodilation, watering eye and nose, salivation and collapse, well known indicators of histamine release seen after administration of donetidine.

Approval Year

PubMed

Title	Date	PubMed
Analysis of drugs from biological fluids using disposable solid phase columns.	1987 Dec 18	2895114
SK&F 93574, a histamine H2-receptor antagonist, releases histamine in the dog.	1989 Jan	2469790

Sample Use Guides

In Vivo Use Guide

A single infusion of 2.5 mg/kg (0.5 ml/kg/min for 2 minutes). The treatments were given at 14-day intervals.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:37:14 GMT 2023` Edited by `admin` on `Fri Dec 15 15:37:14 GMT 2023`
Record UNII	E9730RXS4H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DONETIDINE

Official Name

English

donetidine [INN]

Common Name

English

SK&F 93574

Code

English

DONETIDINE [USAN]

Common Name

English

SK&F-93574

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29702