Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H31NO5 |
| Molecular Weight | 401.4959 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)COC1=C(C)C=C(CCN[C@@H](C)[C@H](O)C2=CC=C(O)C=C2)C(C)=C1
InChI
InChIKey=SLXOKVKOBXCWCK-SBUREZEXSA-N
InChI=1S/C23H31NO5/c1-5-28-22(26)14-29-21-13-15(2)19(12-16(21)3)10-11-24-17(4)23(27)18-6-8-20(25)9-7-18/h6-9,12-13,17,23-25,27H,5,10-11,14H2,1-4H3/t17-,23-/m0/s1
| Molecular Formula | C23H31NO5 |
| Molecular Weight | 401.4959 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Ritobegron (KUC 7483) is a selective β3-adrenoceptor agonist that was developed for oral treatment of overactive bladder. It is the prodrug of the active compound KUC-7322. Phase I studies have investigated the pharmacodynamic and pharmacokinetic effects of ritobegron in healthy individuals and patients with spinal cord injury. Ritobegron exhibits a high selectivity for the bladder versus other organs, and decreased intravesical pressure with minimal effects on the cardiovascular system in rats. When administered in combination with organic anion transporter (OAT) inhibitors such as probenecid (primarily used in treating gout and hyperuricemia), the plasma concentration of the active compound KUC-7322 may increase.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:31:09 GMT 2023
by
admin
on
Sat Dec 16 05:31:09 GMT 2023
|
| Record UNII |
E89L9L8KFH
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID30180263
Created by
admin on Sat Dec 16 05:31:10 GMT 2023 , Edited by admin on Sat Dec 16 05:31:10 GMT 2023
|
PRIMARY | |||
|
E89L9L8KFH
Created by
admin on Sat Dec 16 05:31:10 GMT 2023 , Edited by admin on Sat Dec 16 05:31:10 GMT 2023
|
PRIMARY | |||
|
9810282
Created by
admin on Sat Dec 16 05:31:10 GMT 2023 , Edited by admin on Sat Dec 16 05:31:10 GMT 2023
|
PRIMARY | |||
|
255733-81-4
Created by
admin on Sat Dec 16 05:31:10 GMT 2023 , Edited by admin on Sat Dec 16 05:31:10 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
SALT/SOLVATE -> PARENT |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
METABOLITE ACTIVE -> PRODRUG |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
|