U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 06:48:22 GMT 2025
Edited
by admin
on Wed Apr 02 06:48:22 GMT 2025
Protein Type REGULATOR PROTEIN
Protein Sub Type INITIATION-FACTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
E7D5919XXG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EIF-2B
Preferred Name English
TRANSLATION INITIATION FACTOR EIF-2B
Common Name English
EIF2B
Common Name English
Code System Code Type Description
FDA UNII
E7D5919XXG
Created by admin on Wed Apr 02 06:48:22 GMT 2025 , Edited by admin on Wed Apr 02 06:48:22 GMT 2025
PRIMARY
Related Record Type Details
ACTIVATOR -> TARGET
DNL343 is a selective, orally bioavailable, central nervous system (CNS)–penetrant activator of eukaryotic translation initiation factor 2B (eIF2B).
PRECLINICAL

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [3_1] N-TERMINUS N-ACETYLMETHIONINE 9J12WX5B6A
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS N-ACETYLALANINE 26C4VY6Z0M
AMINO_ACID_SUBSTITUTION [1_18] SITE_SPECIFIC TILARGININE 27JT06E6GR
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL