TOPRILIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H25N3O
Molecular Weight	311.4213
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C=CC=C1)N2CCN(CCCOC3=NC=CC=C3)CC2

InChI

InChIKey=CRXVPWCHOPXHMN-UHFFFAOYSA-N

InChI=1S/C19H25N3O/c1-17-7-2-3-8-18(17)22-14-12-21(13-15-22)11-6-16-23-19-9-4-5-10-20-19/h2-5,7-10H,6,11-16H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H25N3O
Molecular Weight	311.4213
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1301, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | (1974) Psychopharmacology Abstracts, page 386, retrieved from: https://books.google.ru/books?id=SWN1BJg2a4EC

Toprilidine is an active peripheral vasodilator and sedative agent. 1 to 1.5 ug given intraarterially augmented the blood flow in the Arteria femoralis of dogs by 100%. Five microg/kg i.v. increased the blood flow in the Arteria femoralis in six dogs on an average by 32%.

Approval Year

PubMed

Title	Date	PubMed
Designing sedative/hypnotic compounds from a novel substructural graph-theoretical approach.	1998 Nov	9879506

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:50:01 GMT 2023` Edited by `admin` on `Fri Dec 15 15:50:01 GMT 2023`
Record UNII	E66RIC936T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TOPRILIDINE

Official Name

English

toprilidine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29756