2-AMINOBENZIMIDAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H7N3
Molecular Weight	133.1506
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC2=C(N1)C=CC=C2

InChI

InChIKey=JWYUFVNJZUSCSM-UHFFFAOYSA-N

InChI=1S/C7H7N3/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H3,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C7H7N3
Molecular Weight	133.1506
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Isolation and characterization of Pseudomonas sp. CBW capable of degrading carbendazim.	2010-11	20383655
Biodegradation of carbendazim by a novel actinobacterium Rhodococcus jialingiae djl-6-2.	2010-10	20833408
Experimental and theoretical studies on the mechanism of photochemical hydrogen transfer from 2-aminobenzimidazole to nπ* and ππ* aromatic ketones.	2010-09-16	20735030
Fragment-based discovery and optimization of BACE1 inhibitors.	2010-09-01	20656487
Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules.	2010-06-24	20481485
The leucine zipper domains of the transcription factors GCN4 and c-Jun have ribonuclease activity.	2010-05-21	20505831
Experimental and theoretical (DFT) characterization of the excited states and N-centered radical species derived from 2-aminobenzimidazole, the core substructure of a family of bioactive compounds.	2010-05-20	20423160
The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia.	2010-05-01	20347297
3,4-Dimethyl-1H-1,2,4-triazepino[2,3-a]benzimidazol-2(3H)-one.	2010-04-17	21579146
Zinc fingered: new compounds that thwart gram-positive biofilm formation by sequestering zinc.	2010-04-12	20191651
Design, synthesis, and in vitro antiproliferative activity of benzimidazole analogues for radiopharmaceutical efficacy.	2010-04	20423239
Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C.	2010-03-19	20141195
Concise synthesis of 2, 3-diarylpyrimido[1,2-a]benzimidazole based on isoflavones.	2010-03-08	20039759
Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles.	2010-02-01	20015651
The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.	2010-01-15	20044260
2-Aminobenzimidazoles as potent Aurora kinase inhibitors.	2009-09-01	19646866
Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.	2009-08-01	19553115
Simultaneous analysis of thiabendazole, carbendazim and 2-aminobenzimidazole in concentrated fruit juices by liquid chromatography after a single mix-mode solid-phase extraction cleanup.	2009-08	20183067
A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.	2009-07-29	19621946
Ethyl 5-[(1H-benzoimidazol-2-yl)amino-carbon-yl]-4-hydr-oxy-2-methyl-6-oxo-1-propyl-1,6-dihydro-pyridine-3-carboxyl-ate-ethanol-methanol (4/2/1).	2009-07-25	21583660
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.	2009-07-23	19527033
2-Amino-6-nitro-1H-benzoimidazol-3-ium chloride.	2009-07-18	21583609
Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists.	2009-07-01	19457661
[Characterization of a carbendazim-degrading Trichoderma sp. T2-2 and its application in bioremediation].	2009-07	19873757
QSAR analysis of 2-amino or 2-methyl-1-substituted benzimidazoles against Pseudomonas aeruginosa.	2009-04-17	19468332
New sensitive kinetic spectrophotometric methods for determination of omeprazole in dosage forms.	2009	20140076
IRAK-4 inhibitors for inflammation.	2009	19689377
2-Amino-benzimidazolium hydrogen sulfate.	2008-12-13	21581577
2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket.	2008-12-01	18930400
2-Amino-1H-benzoimidazol-3-ium 4,4,4-trifluoro-1,3-dioxo-1-phenyl-butan-2-ide.	2008-11-26	21581428
Discovery of potent, orally active benzimidazole glucagon receptor antagonists.	2008-07-01	18539028
A three component one-pot procedure for the synthesis of [1,2,4]triazolo/benzimidazolo-quinazolinone derivatives in the presence of H6P2W18O(62).18H2O as a green and reusable catalyst.	2008-06-05	18780153
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3.	2008-04-01	18337097
Reaction of nitrilimines with 2-substituted aza-heterocycles. Synthesis of pyrrolo[1,2-a]pyridine and pyrimido[2,1-d]1,2,3,5- tetrazine.	2008-01-28	18259139
Synthesis, structure and biological activities of cobalt(II) and zinc(II) coordination compounds with 2-benzimidazole derivatives.	2007-11-13	18304644
Synthesis and antitrichinellosis activity of some bis(benzimidazol-2-yl)amines.	2007-09-15	17600722
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.	2007-06-01	17395469
Benzimidazole condensed ring systems: new synthesis and antineoplastic activity of substituted 3,4-dihydro- and 1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyrimidine derivatives.	2007-06	17679543
Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones.	2007-03-05	17338816
Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B.	2007-02	17202246
Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles.	2007-01-05	17194083
Synthesis of tetrahydrobenzimidazo[1,2-b]quinazolin-1(2H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one ring systems under solvent-free conditions.	2006-12	17168682
An in vitro investigation on acid catalyzed reactions of proton pump inhibitors in the absence of an electrophile.	2006-10-12	16860502
Toward bifunctional antibody catalysis.	2006-09-15	16782349
Synthesis and QSAR studies of novel 1-substituted-2-aminobenzimidazoles derivatives.	2006-09	16828523
Isolation and characterization of a carbendazim-degrading Rhodococcus sp. djl-6.	2006-07	16775791
Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series.	2006-03-01	16263297
A novel one-pot three-component reaction: synthesis of triheterocyclic 4H-pyrimido[2,1-b]benzazoles ring systems.	2005-12-15	16236502
In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors.	2005-12-01	16203145
Validation of a histamine H3 receptor model through structure-activity relationships for classical H3 antagonists.	2005-10-01	16085419

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:46:58 GMT 2025` Edited by `admin` on `Mon Mar 31 18:46:58 GMT 2025`
Record UNII	E65DE7521V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-AMINOBENZIMIDAZOLE

Systematic Name

English

NSC-27793

Preferred Name

English

AMINOBENZIMIDAZOLE, 2-

Systematic Name

English

1H-BENZIMIDAZOL-2-AMINE

Systematic Name

English

NSC-7628

Code

English

Code System Code Type Description

CAS

934-32-7