IMPROMIDINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H23N7S.3ClH
Molecular Weight	430.827
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.Cl.CC1=C(CSCCNC(=N)NCCCC2=CNC=N2)N=CN1

InChI

InChIKey=HNQSXVXPLCRZNZ-UHFFFAOYSA-N

InChI=1S/C14H23N7S.3ClH/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12;;;/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18);3*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C14H23N7S
Molecular Weight	321.444
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17206612 | https://www.ncbi.nlm.nih.gov/pubmed/8520976 | https://www.ncbi.nlm.nih.gov/pubmed/8565080 | https://www.ncbi.nlm.nih.gov/pubmed/6235604

Impromidine is a highly potent and specific histamine H2 receptor agonist used diagnostically as a gastric secretion indicator. The value of impromidine as an effective acid-secretory stimulant is limited by its tendency to cause cardiovascular side-effects, that mediated by H2-receptors in the cardiovascular system.

Originator

Approval Year

PubMed

Title	Date	PubMed
Histamine and hepatic glutathione in the mouse.	1987 May 25	2884542
Histamine release in the isolated vascularly perfused stomach of the rat: regulation by autoreceptors.	1989 Mar	2470453
Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.	1994 Jun	7976808
H3 receptor-mediated inhibition of intestinal acetylcholine release: pharmacological characterization of signal transduction pathways.	2001 Feb	11219402

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:01:08 GMT 2023` Edited by `admin` on `Fri Dec 15 16:01:08 GMT 2023`
Record UNII	E57WP5Y41J
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IMPROMIDINE HYDROCHLORIDE

Official Name

English

IMPROMIDINE HYDROCHLORIDE [USAN]

Common Name

English

IMPROMIDINE HCL

Common Name

English

GUANIDINE, N-(3-(1H-IMIDAZOL-4-YL)PROPYL)-N'-(2-(((5-METHYL-1H-IMIDAZOL-4-YL)METHYL)THIO)ETHYL)-, TRIHYDROCHLORIDE

Common Name

English

1-(3-Imidazol-4-ylpropyl)-3-[2-[[(5-methylimidazol-4-yl)methyl]thio]ethyl]guanidine trihydrochloride

Systematic Name

English

SK&F 92676-A(SUB 3)

Code

English

SK&F-92676-A3

Code

English

SK&F 92676-A3

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1937