Rondaptivon Pegol

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 11:07:41 GMT 2025` Edited by `admin` on `Wed Apr 02 11:07:41 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Type	COMPLETE
Record UNII	E4U6Y5R3KZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BT-200 FREE ACID

Preferred Name

English

Rondaptivon Pegol

Official Name

English

all-P-ambo-5'-O-(1-hydroxy-14-[?-methylpoly(oxyethylene)-?-oxy]-12-{[?-methylpoly(oxyethylene)-?-oxy]ethyl}-1,10,13-trioxo-2-oxa-9,12-diaza-1? 5 -phosphatetradecan-1-yl)-2'-O-methylguanylyl-(3'?5')-2'-O-methylcytidylyl-(3'?5')-2'-O-methylcytidylyl-(3'?5'

Common Name

English

RNA, (Gm-Cm-Cm-Am-Gm-Gm-Gm-Am-Cm-Cm-Um-Am-Am-Gm-Am-Cm-Am-Cm-Am-Um-Gm-Um-Cm-Cm-Cm-Um-Gm-Gm-Cm-(3??3?)-dT), 5?-[6-[[2-[(2-hydroxyacetyl)(2-hydroxyethyl)amino]acetyl]amino]hexyl hydrogen phosphate], 5?,5?-diether with ?-hydro-?-methoxypoly(oxy-1,2-ethanediy

Common Name

English

RONDAPTIVON PEGOL [USAN]

Common Name

English

rondaptivon pegol [INN]

Common Name

English

BT200 FREE ACID

Code

English

Code System Code Type Description

FDA UNII

E4U6Y5R3KZ

Created by admin on Wed Apr 02 11:07:41 GMT 2025 , Edited by admin on Wed Apr 02 11:07:41 GMT 2025

PRIMARY

SMS_ID

300000009251

Created by admin on Wed Apr 02 11:07:41 GMT 2025 , Edited by admin on Wed Apr 02 11:07:41 GMT 2025

PRIMARY

CAS

2573048-75-4

Created by admin on Wed Apr 02 11:07:41 GMT 2025 , Edited by admin on Wed Apr 02 11:07:41 GMT 2025

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NCI_THESAURUS

C203243

Created by admin on Wed Apr 02 11:07:41 GMT 2025 , Edited by admin on Wed Apr 02 11:07:41 GMT 2025

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INN

12620

Created by admin on Wed Apr 02 11:07:41 GMT 2025 , Edited by admin on Wed Apr 02 11:07:41 GMT 2025

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USAN

KL-127

Created by admin on Wed Apr 02 11:07:41 GMT 2025 , Edited by admin on Wed Apr 02 11:07:41 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_29	29 / 30
	1_30	1 / 30

Linkage	Site Range	Site Count
Phosphate	1_2-1_30	29 / 29

Related Record Type Details


					E4U6Y5R3KZ

Rondaptivon Pegol

ACTIVE MOIETY

Comments:

Binds specifically to the A1 domain of von Willebrand factor and reduces systemic clearance of the von Willebrand factor/Factor VIII complex via the hepatic low density lipoprotein receptorrelated protein 1 (LRP1) receptor

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	100db55d (not in database)