Rondaptivon Pegol

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 18:25:27 GMT 2023` Edited by `admin` on `Sat Dec 16 18:25:27 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	E4U6Y5R3KZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Rondaptivon Pegol

Official Name

English

BT-200 FREE ACID

Code

English

RNA, (Gm-Cm-Cm-Am-Gm-Gm-Gm-Am-Cm-Cm-Um-Am-Am-Gm-Am-Cm-Am-Cm-Am-Um-Gm-Um-Cm-Cm-Cm-Um-Gm-Gm-Cm-(3′→3′)-dT), 5′-[6-[[2-[(2-hydroxyacetyl)(2-hydroxyethyl)amino]acetyl]amino]hexyl hydrogen phosphate], 5′,5′-diether with α-hydro-ω-methoxypoly(oxy

Common Name

English

RONDAPTIVON PEGOL [USAN]

Common Name

English

BT200 FREE ACID

Code

English

Code System Code Type Description

FDA UNII

E4U6Y5R3KZ

Created by admin on Sat Dec 16 18:25:27 GMT 2023 , Edited by admin on Sat Dec 16 18:25:27 GMT 2023

PRIMARY

CAS

2573048-75-4

Created by admin on Sat Dec 16 18:25:27 GMT 2023 , Edited by admin on Sat Dec 16 18:25:27 GMT 2023

PRIMARY

INN

12620

Created by admin on Sat Dec 16 18:25:27 GMT 2023 , Edited by admin on Sat Dec 16 18:25:27 GMT 2023

PRIMARY

USAN

KL-127

Created by admin on Sat Dec 16 18:25:27 GMT 2023 , Edited by admin on Sat Dec 16 18:25:27 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_29	29 / 30
	1_30	1 / 30

Linkage	Site Range	Site Count
Phosphate	1_2-1_30	29 / 29

Related Record Type Details


					E4U6Y5R3KZ

Rondaptivon Pegol

ACTIVE MOIETY

Comments:

Binds specifically to the A1 domain of von Willebrand factor and reduces systemic clearance of the von Willebrand factor/Factor VIII complex via the hepatic low density lipoprotein receptorrelated protein 1 (LRP1) receptor

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	100db55d (not in database)