THENYLDIAMINE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H19N3S
Molecular Weight	261.386
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCN(CC1=CSC=C1)C2=CC=CC=N2

InChI

InChIKey=RCGYDFVCAAKKNG-UHFFFAOYSA-N

InChI=1S/C14H19N3S/c1-16(2)8-9-17(11-13-6-10-18-12-13)14-5-3-4-7-15-14/h3-7,10,12H,8-9,11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C14H19N3S
Molecular Weight	261.386
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18963353

There is not much available information about thenyldiamine, is known, that it is used as antihistamine and for the treatment of asthma and bronchitis.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Asthma 241 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18963353	Primary		Not Provided 504	Unknown Approved Use Unknown
Bronchitis 51 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18963353	Primary		Not Provided 504	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
AAA Chemistry	AR-1I3659
ABI Chem	AC1L1NXG
ABI Chem	AC1Q4X41
Alfa Chemistry	91-79-2	https://www.alfa-chemistry.com/cas_91-79-2.htm
Ambinter	Amb22733161	http://www.ambinter.com/reference/22733161
BOC Sciences	958-93-0
ChemMol	99173755	http://www.chemmol.com/chemmol/99173755.html
Chemieliva Pharmaceutical Co., Ltd	PBCM1466833
Hairui	HR140813
HongKong Chemhere	SCE20739
NovoSeek	7066
THE BioTek	bt-305537	https://www.thebiotek.com/product/others/bt-305537
ZINC	ZINC000000002149	http://zinc15.docking.org/substances/ZINC000000002149
eMolecules	110011951

PubMed

Title	Date	PubMed
Isoetharine methanesulfonate with phenylephrine hydrochloride and thenyldiamine (Bronkometer) in hypertensive and sympathomimetic amine-sensitive asthmatic patients.	1967 Feb	4381226
Trace determination of the antihistamines tripelennamine hydrochloride, thenyldiamine hydrochloride, and chlorothen citrate in admixture in animal feed, human urine, and wastewater by high-pressure liquid chromatography and use of a fluorescence detector.	1983 Apr	18963353
Mutagenicity of amine drugs and their products of nitrosation.	1984 Feb	6363913
Direct analysis of microbial extracts containing metabolites of ethylenediamine-type antihistamines via high-performance liquid chromatography-thermospray mass spectrometry.	1990 Feb 15	1971499

Sample Use Guides

In Vivo Use Guide

in mice: Thenyldiamine was administered as an admixture in the feed to male and female B6C3F, mice for 14 days or for 90 days. Dose levels of 0, 250, 500, 1000, 2000, and 4000 ppm thenyldiamine.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:32:18 GMT 2023` Edited by `admin` on `Fri Dec 15 15:32:18 GMT 2023`
Record UNII	E4U52363JE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THENYLDIAMINE

Official Name

English

THENYLDIAMINE [HSDB]

Common Name

English

Thenyldiamine [WHO-DD]

Common Name

English

2-((2-(DIMETHYLAMINO)ETHYL)-3-THENYLAMINO)PYRIDINE

Systematic Name

English

thenyldiamine [INN]

Common Name

English

THENYLDIAMINE [MI]

Common Name

English

PYRIDINE, 2-((2-(DIMETHYLAMINO)ETHYL)-3-THENYLAMINO)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578