Budoprutug

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 18:45:41 GMT 2023` Edited by `admin` on `Sat Dec 16 18:45:41 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	E4ET672BAP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Budoprutug

Official Name

English

VB119

Code

English

Gamma1 heavy chain (1-450) [VH Musmus/Homsap (Mus musculus IGHV1-69*02(85.7%) -(IGHD) -IGHJ4*01(100%)/Homo sapiens IGHV1-46*01 (67.3%) -(IGHD) - IGHJ4*01 (92.3%) L123>S (115), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03 (100%),

Common Name

English

VB-119

Code

English

Immunoglobulin G1 [de-450-lysine], anti-(human CD19 antigen) (human-Mus musculus monoclonal VB119 γ1-chain), disulfide with human-Mus musculus monoclonal VB119 κ-chain, dimer

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens CD19 (B lymphocyte surface antigen B4, Leu-12)], monoclonal antibody

Common Name

English

budoprutug [INN]

Common Name

English

Code System Code Type Description

CAS

2720478-38-4

Created by admin on Sat Dec 16 18:45:41 GMT 2023 , Edited by admin on Sat Dec 16 18:45:41 GMT 2023

PRIMARY

INN

12546

Created by admin on Sat Dec 16 18:45:41 GMT 2023 , Edited by admin on Sat Dec 16 18:45:41 GMT 2023

PRIMARY

FDA UNII

E4ET672BAP

Created by admin on Sat Dec 16 18:45:41 GMT 2023 , Edited by admin on Sat Dec 16 18:45:41 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_211
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_87
3_131	3_191
4_23	4_87
4_131	4_191
1_223	3_211
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					IYZ9TI08W3

B-LYMPHOCYTE ANTIGEN CD19

TARGET->LIGAND

Interaction Type:

IN-VITRO, IN-VIVO

Amount:

Related Record Type Details


					E4ET672BAP

Budoprutug

ACTIVE MOIETY

Comments:

VB119 has been shown to reduce serum B-cell populations in a Phase 1 clinical trial

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL