Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H16BNO |
Molecular Weight | 225.094 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NCCOB(C1=CC=CC=C1)C2=CC=CC=C2
InChI
InChIKey=BLZVCIGGICSWIG-UHFFFAOYSA-N
InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
Molecular Formula | C14H16BNO |
Molecular Weight | 225.094 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL1250402 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24304219 |
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Target ID: CHEMBL5522 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16408004 |
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Target ID: CHEMBL5051 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16408004 |
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Target ID: CHEMBL4794 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16408004 |
PubMed
Title | Date | PubMed |
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Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells. | 2006 |
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Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension. | 2007 Apr |
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2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo. | 2007 Apr 11 |
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Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities. | 2007 Feb 2 |
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2-Aminoethyl diphenylborinate analogues: selective inhibition for store-operated Ca2+ entry. | 2007 Jan 12 |
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Role of TRPV1 and intracellular Ca2+ in excitation of cardiac sensory neurons by bradykinin. | 2007 Jul |
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Metabotropic glutamate receptors in the lateral superior olive activate TRP-like channels: age- and experience-dependent regulation. | 2007 May |
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Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence. | 2007 May 25 |
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Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor. | 2007 May 29 |
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Human malarial parasite, Plasmodium falciparum, displays capacitative calcium entry: 2-aminoethyl diphenylborinate blocks the signal transduction pathway of melatonin action on the P. falciparum cell cycle. | 2007 Nov |
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Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. | 2007 Nov |
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Monocytes from spontaneously hypertensive rats show increased store-operated and second messenger-operated calcium influx mediated by transient receptor potential canonical Type 3 channels. | 2007 Oct |
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Ca2+-dependent ATP release from A549 cells involves synergistic autocrine stimulation by coreleased uridine nucleotides. | 2007 Oct 15 |
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A nitric oxide/Ca(2+)/calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1beta in human astrocytoma cells. | 2008 Apr |
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Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells. | 2008 Aug |
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Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). | 2008 Dec |
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Initial and extended inflammatory messages of the nongenomic signaling pathway of the TCDD-activated Ah receptor in U937 macrophages. | 2008 Dec 15 |
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Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas. | 2008 Feb |
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Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry. | 2008 Feb |
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Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance. | 2008 Feb 8 |
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Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange. | 2008 Jan |
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Roles of cytosolic phospholipase A2 and Src kinase in the early action of 2,3,7,8-tetrachlorodibenzo-p-dioxin through a nongenomic pathway in MCF10A cells. | 2008 Jul |
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Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Müller cells. | 2008 Jul |
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TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008 Jun 11 |
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Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). | 2008 Mar |
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Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries. | 2008 Mar |
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Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. | 2008 Mar |
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Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells. | 2008 Nov |
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Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. | 2008 Nov |
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Sustained depolarization-induced propagation of [Ca2+]i oscillations in cultured DRG neurons: the involvement of extracellular ATP and P2Y receptor activation. | 2008 Nov 6 |
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Alcohol induces relaxation of rat thoracic aorta and mesenteric arterial bed. | 2008 Sep-Oct |
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Two chromogranin a-derived peptides induce calcium entry in human neutrophils by calmodulin-regulated calcium independent phospholipase A2. | 2009 |
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The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection. | 2009 Aug |
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Clodronate-induced cell apoptosis in human thyroid carcinoma is mediated via the P2 receptor signaling pathway. | 2009 Aug |
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Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons. | 2009 Dec |
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Transient receptor potential canonical type 3 channels and blood pressure in humans. | 2009 Jun |
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N-acyldopamines control striatal input terminals via novel ligand-gated cation channels. | 2009 Mar |
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Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons. | 2009 Mar |
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Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus. | 2009 Mar 15 |
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Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons. | 2009 May |
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Water deficit alters differentially metabolic pathways affecting important flavor and quality traits in grape berries of Cabernet Sauvignon and Chardonnay. | 2009 May 8 |
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In vitro vasorelaxation mechanisms of bioactive compounds extracted from Hibiscus sabdariffa on rat thoracic aorta. | 2009 Nov 2 |
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Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. | 2009 Nov 27 |
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Trichlorfon induces apoptosis in SH-SY5Y neuroblastoma cells via the endoplasmic reticulum? | 2009 Sep 14 |
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Signal transduction mechanisms underlying group I mGluR-mediated increase in frequency and amplitude of spontaneous EPSCs in the spinal trigeminal subnucleus oralis of the rat. | 2009 Sep 2 |
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Mechanisms of action of hydrogen sulfide in relaxation of mouse distal colonic smooth muscle. | 2010 Feb 25 |
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Glucose enhances expression of TRPC1 and calcium entry in endothelial cells. | 2010 Jan |
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Characterization of spontaneous inhibitory postsynaptic currents in cultured rat retinal amacrine cells. | 2010 Jan 20 |
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NO contributes to abnormal vascular calcium regulation and reactivity induced by peritonitis-associated septic shock in rats. | 2010 May |
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Increased rhythmicity in hypertensive arterial smooth muscle is linked to transient receptor potential canonical channels. | 2010 Oct |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:21:23 GMT 2023
by
admin
on
Sat Dec 16 08:21:23 GMT 2023
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Record UNII |
E4ES684O93
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Record Status |
Validated (UNII)
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Record Version |
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2-Aminoethoxydiphenyl borate
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17107
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E4ES684O93
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208-366-5
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524-95-8
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DTXSID0040389
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1598
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