Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H16BNO |
| Molecular Weight | 225.094 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCCOB(C1=CC=CC=C1)C2=CC=CC=C2
InChI
InChIKey=BLZVCIGGICSWIG-UHFFFAOYSA-N
InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
| Molecular Formula | C14H16BNO |
| Molecular Weight | 225.094 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL1250402 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24304219 |
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Target ID: CHEMBL5522 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16408004 |
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Target ID: CHEMBL5051 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16408004 |
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Target ID: CHEMBL4794 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16408004 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Increased rhythmicity in hypertensive arterial smooth muscle is linked to transient receptor potential canonical channels. | 2010-10 |
|
| NO contributes to abnormal vascular calcium regulation and reactivity induced by peritonitis-associated septic shock in rats. | 2010-05 |
|
| Mechanisms of action of hydrogen sulfide in relaxation of mouse distal colonic smooth muscle. | 2010-02-25 |
|
| Characterization of spontaneous inhibitory postsynaptic currents in cultured rat retinal amacrine cells. | 2010-01-20 |
|
| Glucose enhances expression of TRPC1 and calcium entry in endothelial cells. | 2010-01 |
|
| Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons. | 2009-12 |
|
| Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. | 2009-11-27 |
|
| In vitro vasorelaxation mechanisms of bioactive compounds extracted from Hibiscus sabdariffa on rat thoracic aorta. | 2009-11-02 |
|
| Trichlorfon induces apoptosis in SH-SY5Y neuroblastoma cells via the endoplasmic reticulum? | 2009-09-14 |
|
| Signal transduction mechanisms underlying group I mGluR-mediated increase in frequency and amplitude of spontaneous EPSCs in the spinal trigeminal subnucleus oralis of the rat. | 2009-09-02 |
|
| The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection. | 2009-08 |
|
| Clodronate-induced cell apoptosis in human thyroid carcinoma is mediated via the P2 receptor signaling pathway. | 2009-08 |
|
| Transient receptor potential canonical type 3 channels and blood pressure in humans. | 2009-06 |
|
| Water deficit alters differentially metabolic pathways affecting important flavor and quality traits in grape berries of Cabernet Sauvignon and Chardonnay. | 2009-05-08 |
|
| Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons. | 2009-05 |
|
| Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus. | 2009-03-15 |
|
| N-acyldopamines control striatal input terminals via novel ligand-gated cation channels. | 2009-03 |
|
| Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons. | 2009-03 |
|
| Two chromogranin a-derived peptides induce calcium entry in human neutrophils by calmodulin-regulated calcium independent phospholipase A2. | 2009 |
|
| Initial and extended inflammatory messages of the nongenomic signaling pathway of the TCDD-activated Ah receptor in U937 macrophages. | 2008-12-15 |
|
| Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). | 2008-12 |
|
| Sustained depolarization-induced propagation of [Ca2+]i oscillations in cultured DRG neurons: the involvement of extracellular ATP and P2Y receptor activation. | 2008-11-06 |
|
| Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells. | 2008-11 |
|
| Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. | 2008-11 |
|
| Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells. | 2008-08 |
|
| Roles of cytosolic phospholipase A2 and Src kinase in the early action of 2,3,7,8-tetrachlorodibenzo-p-dioxin through a nongenomic pathway in MCF10A cells. | 2008-07 |
|
| Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Müller cells. | 2008-07 |
|
| TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008-06-11 |
|
| Alcohol induces relaxation of rat thoracic aorta and mesenteric arterial bed. | 2008-05-23 |
|
| A nitric oxide/Ca(2+)/calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1beta in human astrocytoma cells. | 2008-04 |
|
| Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). | 2008-03 |
|
| Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries. | 2008-03 |
|
| Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. | 2008-03 |
|
| Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance. | 2008-02-08 |
|
| Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas. | 2008-02 |
|
| Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry. | 2008-02 |
|
| Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange. | 2008-01 |
|
| Human malarial parasite, Plasmodium falciparum, displays capacitative calcium entry: 2-aminoethyl diphenylborinate blocks the signal transduction pathway of melatonin action on the P. falciparum cell cycle. | 2007-11 |
|
| Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. | 2007-11 |
|
| Ca2+-dependent ATP release from A549 cells involves synergistic autocrine stimulation by coreleased uridine nucleotides. | 2007-10-15 |
|
| Monocytes from spontaneously hypertensive rats show increased store-operated and second messenger-operated calcium influx mediated by transient receptor potential canonical Type 3 channels. | 2007-10 |
|
| Role of TRPV1 and intracellular Ca2+ in excitation of cardiac sensory neurons by bradykinin. | 2007-07 |
|
| Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor. | 2007-05-29 |
|
| Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence. | 2007-05-25 |
|
| Metabotropic glutamate receptors in the lateral superior olive activate TRP-like channels: age- and experience-dependent regulation. | 2007-05 |
|
| 2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo. | 2007-04-11 |
|
| Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension. | 2007-04 |
|
| Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities. | 2007-02-02 |
|
| 2-Aminoethyl diphenylborinate analogues: selective inhibition for store-operated Ca2+ entry. | 2007-01-12 |
|
| Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells. | 2006 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:01:22 GMT 2025
by
admin
on
Mon Mar 31 22:01:22 GMT 2025
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| Record UNII |
E4ES684O93
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| Record Status |
Validated (UNII)
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| Record Version |
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2-Aminoethoxydiphenyl borate
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17107
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E4ES684O93
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208-366-5
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524-95-8
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DTXSID0040389
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1598
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