RETICULOL

COC1=C(O)C=C2C=C(C)OC(=O)C2=C1O

InChIKey=LREZRXWUEZCZRU-UHFFFAOYSA-N

InChI=1S/C11H10O5/c1-5-3-6-4-7(12)10(15-2)9(13)8(6)11(14)16-5/h3-4,12-13H,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
DNA topoisomerase 1 16 Target ID: P11387\|\|\|Q9UJN0 Gene ID: 7150.0 Gene Symbol: TOP1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/14504438	Inhibitor 8504
cyclic nucleotide phosphodiesterase) 1 Target ID: cyclic nucleotide phosphodiesterase) Sources: https://www.ncbi.nlm.nih.gov/pubmed/168174	Inhibitor 8504		41.0 µM [IC50]

PubMed

Title	Date	PubMed
Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma.	2003-09	14504438
Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma.	2003-06	12815208
Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase.	1975-07	168174

Substance Class	Chemical Created by `admin` on `Tue Apr 01 19:48:43 GMT 2025` Edited by `admin` on `Tue Apr 01 19:48:43 GMT 2025`
Record UNII	E2RA5C4YRR
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

NSC-294978

Preferred Name

English

RETICULOL

Common Name

English

6,8-Dihydroxy-7-methoxy-3-methylisocoumarin

Systematic Name

English

Isocoumarin, 6,8-dihydroxy-7-methoxy-3-methyl-

Common Name

English

1H-2-Benzopyran-1-one, 6,8-dihydroxy-7-methoxy-3-methyl-

Systematic Name

English

K-251-1

Common Name

English

6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one

Systematic Name

English

Code System Code Type Description

NSC

294978