RETICULOL

COC1=C(O)C=C2C=C(C)OC(=O)C2=C1O

InChIKey=LREZRXWUEZCZRU-UHFFFAOYSA-N

InChI=1S/C11H10O5/c1-5-3-6-4-7(12)10(15-2)9(13)8(6)11(14)16-5/h3-4,12-13H,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
DNA topoisomerase 1 16 Target ID: P11387\|\|\|Q9UJN0 Gene ID: 7150.0 Gene Symbol: TOP1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/14504438	Inhibitor 8297
cyclic nucleotide phosphodiesterase) 1 Target ID: cyclic nucleotide phosphodiesterase) Sources: https://www.ncbi.nlm.nih.gov/pubmed/168174	Inhibitor 8297		41.0 µM [IC50]

PubMed

Title	Date	PubMed
Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma.	2003 Jun	12815208

Substance Class	Chemical Created by `admin` on `Sat Dec 16 12:48:29 GMT 2023` Edited by `admin` on `Sat Dec 16 12:48:29 GMT 2023`
Record UNII	E2RA5C4YRR
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

RETICULOL

Common Name

English

NSC-294978

Code

English

6,8-Dihydroxy-7-methoxy-3-methylisocoumarin

Systematic Name

English

Isocoumarin, 6,8-dihydroxy-7-methoxy-3-methyl-

Common Name

English

1H-2-Benzopyran-1-one, 6,8-dihydroxy-7-methoxy-3-methyl-

Systematic Name

English

K-251-1

Common Name

English

6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one

Systematic Name

English

Code System Code Type Description

NSC

294978