THIAMIPRINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8N8O2S
Molecular Weight	292.277
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C=NC(=C1SC2=C3N=CNC3=NC(N)=N2)[N+]([O-])=O

InChI

InChIKey=YFTWHEBLORWGNI-UHFFFAOYSA-N

InChI=1S/C9H8N8O2S/c1-16-3-13-6(17(18)19)8(16)20-7-4-5(12-2-11-4)14-9(10)15-7/h2-3H,1H3,(H3,10,11,12,14,15)

HIDE SMILES / InChI

Molecular Formula	C9H8N8O2S
Molecular Weight	292.277
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13849698 | https://www.ncbi.nlm.nih.gov/pubmed/2738881 | https://www.ncbi.nlm.nih.gov/pubmed/5139795

Thiamiprine is a cytotoxic purine derivative patented by Wellcome Foundation Ltd. as an immunosuppressive and antineoplastic agent. In preclinical models, Thiamiprine is active against a variety of transplantable rodent tumors and in the rat adjuvant arthritis model.

Originator

Approval Year

PubMed

Title	Date	PubMed
Purine analogs as potential anticytomegalovirus agents.	1969 Sep	4309475
[Comparative study of toxicity, immunodepressive and tolerogenic activity of thiamiprine, azathioprine and cyclophosphane].	1971 Nov-Dec	5139795

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:09:11 GMT 2023` Edited by `admin` on `Fri Dec 15 15:09:11 GMT 2023`
Record UNII	E2EV7ZDD1M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIAMIPRINE

Official Name

English

GUANERAN

Common Name

English

BW-57-323

Code

English

BW 57-323

Code

English

AZATHIOPRINE RELATED COMPOUND G

Common Name

English

NSC-38887

Code

English

tiamiprine [INN]

Common Name

English

TIAMIPRINE

Official Name

English

1H-PURIN-2-AMINE, 6-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO)-

Systematic Name

English

AZATHIOPRINE IMPURITY G [EP IMPURITY]

Common Name

English

TIAMIPRIN

Common Name

English

9H-PURIN-2-AMINE, 6-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO)-

Systematic Name

English

THIAMIPRINE [USAN]

Common Name

English

THIAMIPRINE [MI]

Common Name

English

AZATHIOPRINE RELATED COMPOUND G [USP-RS]

Common Name

English

2-Amino-6-[(1-methyl-4-nitroimidazol-5-yl)thio]purine

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1556