Amtabafusp Alfa

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:40:19 GMT 2025` Edited by `admin` on `Wed Apr 02 13:40:19 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	DYX4A3PAK8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Humanized immunoglobulin G1-lambda anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)] monomer disulfide bridged to human T-cell surface glycoprotein CD4 extracellular domain 1, engineered to bind human immunodeficiency virus gp120 envelope glycoprotein, fused

Preferred Name

English

Amtabafusp Alfa

Official Name

English

amtabafusp alfa [INN]

Common Name

English

Code System Code Type Description

INN

13207

Created by admin on Wed Apr 02 13:40:19 GMT 2025 , Edited by admin on Wed Apr 02 13:40:19 GMT 2025

PRIMARY

NCI_THESAURUS

C211766

Created by admin on Wed Apr 02 13:40:19 GMT 2025 , Edited by admin on Wed Apr 02 13:40:19 GMT 2025

PRIMARY

CAS

2839531-84-7

Created by admin on Wed Apr 02 13:40:19 GMT 2025 , Edited by admin on Wed Apr 02 13:40:19 GMT 2025

PRIMARY

FDA UNII

DYX4A3PAK8

Created by admin on Wed Apr 02 13:40:19 GMT 2025 , Edited by admin on Wed Apr 02 13:40:19 GMT 2025

PRIMARY

From	To
3_137	3_196
3_22	3_90
2_248	2_306
2_142	2_202
2_16	2_84
1_375	1_433
1_269	1_329
1_237	2_110
1_234	2_107
1_228	3_214
1_152	1_208
1_22	1_98

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_305
N	2_178

Related Record Type Details


					DYX4A3PAK8

Amtabafusp Alfa

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_1]	N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS	E	Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_455] [2_328]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL