Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H23NO2 |
| Molecular Weight | 249.3486 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNCC(C1=CC=C(O)C=C1)C2(O)CCCCC2
InChI
InChIKey=MMSWXJSQCAEDLK-UHFFFAOYSA-N
InChI=1S/C15H23NO2/c1-16-11-14(12-5-7-13(17)8-6-12)15(18)9-3-2-4-10-15/h5-8,14,16-18H,2-4,9-11H2,1H3
| Molecular Formula | C15H23NO2 |
| Molecular Weight | 249.3486 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
N,O-Didesmethylvenlafaxine is a metabolite of venlafaxine, an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. In humans, venlafaxine is biotransformed for the most part by CYP2D6 and CYP2C19 isoenzymes to its major metabolite O-desmethylvenlafaxine, and in parallel to N-desmethylvenlafaxine and N,O-didesmethylvenlafaxine. It was shown, that CYP2D6 genotype influenced the O-demethylation whereas CYP2C19 influenced the N-demethylation of venlafaxine and its metabolites.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 04:48:48 UTC 2023
by
admin
on
Sat Dec 16 04:48:48 UTC 2023
|
| Record UNII |
DYW3W9739Y
|
| Record Status |
Validated (UNII)
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| Record Version |
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| Code System | Code | Type | Description | ||
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1175795
Created by
admin on Sat Dec 16 04:48:49 UTC 2023 , Edited by admin on Sat Dec 16 04:48:49 UTC 2023
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135308-74-6
Created by
admin on Sat Dec 16 04:48:49 UTC 2023 , Edited by admin on Sat Dec 16 04:48:49 UTC 2023
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3451347
Created by
admin on Sat Dec 16 04:48:49 UTC 2023 , Edited by admin on Sat Dec 16 04:48:49 UTC 2023
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DTXSID10891441
Created by
admin on Sat Dec 16 04:48:49 UTC 2023 , Edited by admin on Sat Dec 16 04:48:49 UTC 2023
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DYW3W9739Y
Created by
admin on Sat Dec 16 04:48:49 UTC 2023 , Edited by admin on Sat Dec 16 04:48:49 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> METABOLITE INACTIVE |
MINOR
|
||
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PARENT -> METABOLITE INACTIVE |
<5% (NODV and NODV-glucuronide);
Unit: percent of amount administered
IN-VIVO
URINE
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| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
