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Details

Stereochemistry ACHIRAL
Molecular Formula C19H27N5.ClH
Molecular Weight 361.912
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DAPIPRAZOLE HYDROCHLORIDE

SMILES

Cl.CC1=C(C=CC=C1)N2CCN(CCC3=NN=C4CCCCN34)CC2

InChI

InChIKey=ZIODNPFQZIHCOE-UHFFFAOYSA-N
InChI=1S/C19H27N5.ClH/c1-16-6-2-3-7-17(16)23-14-12-22(13-15-23)11-9-19-21-20-18-8-4-5-10-24(18)19;/h2-3,6-7H,4-5,8-15H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula C19H27N5
Molecular Weight 325.4512
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/019849_S011_REV-EYES.pdf

Dapiprazole is an alpha-1 adrenergic receptors antagonist which was developed for for the treatment of drug induced mydriasis produced by adrenergic or parasympatholytic agents. The drug was marketed under the name Rev-Eyes, however it was withdrawn from market due to its slow effect.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Secondary
REV-EYES

Approved Use

Dapiprazole hydrochloride 0.5% (Rev-Eyes) is an alpha-adrenergic blocking agent used to reverse pharmacologically induced mydriasis.

Launch Date

1990
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

The recommended dosage is 2 drops (0.5% solution) followed 5 minutes later by 2 drops.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:15:32 GMT 2023
Edited
by admin
on Fri Dec 15 15:15:32 GMT 2023
Record UNII
DS9UJN1I0X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DAPIPRAZOLE HYDROCHLORIDE
MART.   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN  
Official Name English
REV-EYES
Brand Name English
Dapiprazole hydrochloride [WHO-DD]
Common Name English
DAPIPRAZOLE MONOHYDROCHLORIDE
MI  
Common Name English
DAPIPRAZOLE MONOHYDROCHLORIDE [MI]
Common Name English
AF 2139
Code English
DAPIPRAZOLE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
5,6,7,8-Tetrahydro-3-[2-(4-O-tolyl-1-piperazinyl)ethyl]-S-triazolo[4,3-a]pyridine monohydrochloride
Common Name English
DAPIPRAZOLE HYDROCHLORIDE [MART.]
Common Name English
AF-2139
Code English
DAPIPRAZOLE HCL
Common Name English
1,2,4-TRIAZOLO(4,3-A)PYRIDINE, 5,6,7,8-TETRAHYDRO-3-(2-(4-(2-METHYLPHENYL)-1-PIPERAZINYL)ETHYL)-, MONOHYDROCHLORIDE
Common Name English
5,6,7,8-TETRAHYDRO-3-(2-(4-(2-METHYLPHENYL)-1-PIPERAZINYL)ETHYL)-1,2,4-TRIAZOLO(4,3-A)PYRIDINE MONOHYDROCHLORIDE
Systematic Name English
DAPIPRAZOLE HYDROCHLORIDE [USAN]
Common Name English
DAPIPRAZOLE HYDROCHLORIDE [VANDF]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29713
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
Code System Code Type Description
DAILYMED
DS9UJN1I0X
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
RXCUI
235757
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY RxNorm
NCI_THESAURUS
C47469
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
CAS
72822-13-0
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
PUBCHEM
6917787
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
MERCK INDEX
m4090
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY Merck Index
EVMPD
SUB01554MIG
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
SMS_ID
100000084696
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
EPA CompTox
DTXSID7048669
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
USAN
AA-101
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201216
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
FDA UNII
DS9UJN1I0X
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
DRUG BANK
DBSALT001438
Created by admin on Fri Dec 15 15:15:32 GMT 2023 , Edited by admin on Fri Dec 15 15:15:32 GMT 2023
PRIMARY
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