FUB-PB-22

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H17FN2O2
Molecular Weight	396.4131
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(CN2C=C(C(=O)OC3=C4N=CC=CC4=CC=C3)C5=C2C=CC=C5)C=C1

InChI

InChIKey=ROHVURVXAOMRJY-UHFFFAOYSA-N

InChI=1S/C25H17FN2O2/c26-19-12-10-17(11-13-19)15-28-16-21(20-7-1-2-8-22(20)28)25(29)30-23-9-3-5-18-6-4-14-27-24(18)23/h1-14,16H,15H2

HIDE SMILES / InChI

Molecular Formula	C25H17FN2O2
Molecular Weight	396.4131
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26810398 | https://www.ncbi.nlm.nih.gov/pubmed/27429655

FDU-PB-22 (naphthalen-1-yl 1-[(4-fluorophenyl)methyl]-1H-indole-3-carboxylate) is a synthetic cannabinoid. It is considered to be a constituent of illicit smoking mixtures "spice".

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid CB1 receptor 85 Target ID: CHEMBL218 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27429655	Agonist 2752		0.386 nM [Ki]
Cannabinoid CB2 receptor 71 Target ID: CHEMBL253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27429655	Agonist 2752		0.478 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Discrimination between closely related synthetic cannabinoids by GC-Cold-EI-MS.	2018-03	28688175
AB-CHMINACA-induced sudden death from non-cardiogenic pulmonary edema.	2018-02	28707493
New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine.	2017-10-05	28782580
In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22.	2016-03	26810398
Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice.	2016	27429655

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:09:02 GMT 2025` Edited by `admin` on `Mon Mar 31 23:09:02 GMT 2025`
Record UNII	DS46154N3F
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FUB-PB-22

Common Name

English

J3.314.547K

Preferred Name

English

1-(4-FLUOROBENZYL)-1H-INDOLE-3-CARBOXYLIC ACID 8-QUINOLYL ESTER

Systematic Name

English

1H-INDOLE-3-CARBOXYLIC ACID, 1-((4-FLUOROPHENYL)METHYL)-, 8-QUINOLINYL ESTER

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-FUB-PB-22